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- W2068099658 abstract "We investigated the ability of selective opioid agonists and antagonists to influence pro-opiomelanocortin peptide secretion from the rat neurointermediate lobe in vitro. The μ-opioid agonist DAMGO ([D-Ala2, N-Me-Phe4, Gly5-ol]enkephalin) significantly stimulated β-endorphin and α-melanocyte-stimulating hormone release relative to controls early (30 min) in the incubation period. Similar effects on β-endorphin secretion were observed with the selective μ-opioid agonist dermorphin. The δ-opioid receptor agonist DPDPE ([D-Pen2,5]enkephalin) weakly inhibited β-endorphin secretion relative to controls while the κ-opioid receptor agonist U50488 had no effect. The μ-opioid selective antagonist CTOP (D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2) inhibited basal β-endorphin secretion while κ- and δ-opioid receptor antagonists had no effect. Our data support a role for local μ-opioid receptor control of intermediate lobe pro-opiomelanocortin peptide secretion. Peptide secretion from melanotropes appears to be tonically stimulated by activation of μ-opioid receptors in the absence of intact neuronal innervation to the intermediate lobe." @default.
- W2068099658 created "2016-06-24" @default.
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- W2068099658 date "2000-02-01" @default.
- W2068099658 modified "2023-10-16" @default.
- W2068099658 title "Mu and delta opioid receptor regulation of pro-opiomelanocortin peptide secretion from the rat neurointermediate pituitary in vitro" @default.
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- W2068099658 doi "https://doi.org/10.1054/npep.1999.0793" @default.
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