FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068100595> ?p ?o ?g. }

• W2068100595 endingPage "242" @default.
• W2068100595 startingPage "235" @default.
• W2068100595 abstract "In animal models of autoimmunity, CD4 CD25high T cells play a key role in the control of the autoimmune process. Few studies have investigated the role of these cells in human autoimmune diseases. We aimed to investigate CD4 CD25high T cells in the peripheral blood of patients with primary Sjögren's syndrome (pSS). The proportion of blood CD4 CD25high T cells was determined by flow cytometry in 21 patients with pSS as determined by the American–European consensus group criteria and two groups of controls (18 patients with lumbar back pain of mechanical origin and 15 healthy blood donors). The suppressive function of CD4 CD25 cells was assessed using co-culture assays. The Vbeta repertoire of CD4 CD25 T cells was examined by flow cytometry. The proportion of CD4 CD25 T cells depended on age in patients and controls. In an age-matched comparison, no significant difference was observed in the proportion of total CD4 CD25low T cells between patients with pSS and controls (P=0.36). In contrast, the pool of CD4 CD25high was significantly increased in patients with pSS (8.5% vs 4.1% in controls, P=0.04). There was a slight but not significant higher proportion of CD4 CD25high cells in patients with a more active disease. CD4 CD25 T cells in patients with pSS effectively suppressed the proliferation of CD4 CD25− autologous responder T cells. The Vbeta repertoire of regulatory T cells from patients with pSS was polyclonal and was not significantly restricted as compared with that in controls. Functional CD4 CD25high regulatory cells are increased in patients with established pSS, through a reactive feedback, despite ongoing autoimmunity. These results suggest that pSS does not occur as a result of reduced level of CD4 CD25high regulatory T cells, nor as a defect of inhibition of proliferation of responder cells." @default.
• W2068100595 created "2016-06-24" @default.
• W2068100595 creator A5000636027 @default.
• W2068100595 creator A5025160491 @default.
• W2068100595 creator A5044495365 @default.
• W2068100595 creator A5044694543 @default.
• W2068100595 creator A5048911676 @default.
• W2068100595 creator A5050625823 @default.
• W2068100595 creator A5051196993 @default.
• W2068100595 creator A5056200748 @default.
• W2068100595 date "2005-05-01" @default.
• W2068100595 modified "2023-10-17" @default.
• W2068100595 title "CD4 CD25 regulatory T cells are not impaired in patients with primary Sjögren's syndrome" @default.
• W2068100595 cites W140424242 @default.
• W2068100595 cites W1521212256 @default.
• W2068100595 cites W1530044612 @default.
• W2068100595 cites W1560277370 @default.
• W2068100595 cites W1560623534 @default.
• W2068100595 cites W1561046927 @default.
• W2068100595 cites W1790769786 @default.
• W2068100595 cites W1963674865 @default.
• W2068100595 cites W1968855481 @default.
• W2068100595 cites W1978895719 @default.
• W2068100595 cites W1989468646 @default.
• W2068100595 cites W2002726823 @default.
• W2068100595 cites W2005367309 @default.
• W2068100595 cites W2011438680 @default.
• W2068100595 cites W2022833548 @default.
• W2068100595 cites W2028421750 @default.
• W2068100595 cites W2039986138 @default.
• W2068100595 cites W2045236396 @default.
• W2068100595 cites W2052386553 @default.
• W2068100595 cites W2059189040 @default.
• W2068100595 cites W2061037729 @default.
• W2068100595 cites W2080894267 @default.
• W2068100595 cites W2093383759 @default.
• W2068100595 cites W2094798767 @default.
• W2068100595 cites W2118268169 @default.
• W2068100595 cites W2120010406 @default.
• W2068100595 cites W2122445377 @default.
• W2068100595 cites W2135840439 @default.
• W2068100595 cites W2146331182 @default.
• W2068100595 cites W2148245227 @default.
• W2068100595 cites W2150747144 @default.
• W2068100595 cites W2156104527 @default.
• W2068100595 cites W2156959273 @default.
• W2068100595 cites W2168419126 @default.
• W2068100595 cites W2169887956 @default.
• W2068100595 cites W2411913455 @default.
• W2068100595 cites W2792966232 @default.
• W2068100595 doi "https://doi.org/10.1016/j.jaut.2005.01.015" @default.
• W2068100595 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15848046" @default.
• W2068100595 hasPublicationYear "2005" @default.
• W2068100595 type Work @default.
• W2068100595 sameAs 2068100595 @default.
• W2068100595 citedByCount "137" @default.
• W2068100595 countsByYear W20681005952012 @default.
• W2068100595 countsByYear W20681005952013 @default.
• W2068100595 countsByYear W20681005952014 @default.
• W2068100595 countsByYear W20681005952015 @default.
• W2068100595 countsByYear W20681005952016 @default.
• W2068100595 countsByYear W20681005952017 @default.
• W2068100595 countsByYear W20681005952018 @default.
• W2068100595 countsByYear W20681005952019 @default.
• W2068100595 countsByYear W20681005952020 @default.
• W2068100595 countsByYear W20681005952021 @default.
• W2068100595 countsByYear W20681005952022 @default.
• W2068100595 countsByYear W20681005952023 @default.
• W2068100595 crossrefType "journal-article" @default.
• W2068100595 hasAuthorship W2068100595A5000636027 @default.
• W2068100595 hasAuthorship W2068100595A5025160491 @default.
• W2068100595 hasAuthorship W2068100595A5044495365 @default.
• W2068100595 hasAuthorship W2068100595A5044694543 @default.
• W2068100595 hasAuthorship W2068100595A5048911676 @default.
• W2068100595 hasAuthorship W2068100595A5050625823 @default.
• W2068100595 hasAuthorship W2068100595A5051196993 @default.
• W2068100595 hasAuthorship W2068100595A5056200748 @default.
• W2068100595 hasConcept C126322002 @default.
• W2068100595 hasConcept C134018914 @default.
• W2068100595 hasConcept C159654299 @default.
• W2068100595 hasConcept C203014093 @default.
• W2068100595 hasConcept C2776090121 @default.
• W2068100595 hasConcept C2780130043 @default.
• W2068100595 hasConcept C553184892 @default.
• W2068100595 hasConcept C71924100 @default.
• W2068100595 hasConcept C79484868 @default.
• W2068100595 hasConcept C8891405 @default.
• W2068100595 hasConceptScore W2068100595C126322002 @default.
• W2068100595 hasConceptScore W2068100595C134018914 @default.
• W2068100595 hasConceptScore W2068100595C159654299 @default.
• W2068100595 hasConceptScore W2068100595C203014093 @default.
• W2068100595 hasConceptScore W2068100595C2776090121 @default.
• W2068100595 hasConceptScore W2068100595C2780130043 @default.
• W2068100595 hasConceptScore W2068100595C553184892 @default.
• W2068100595 hasConceptScore W2068100595C71924100 @default.
• W2068100595 hasConceptScore W2068100595C79484868 @default.
• W2068100595 hasConceptScore W2068100595C8891405 @default.
• W2068100595 hasIssue "3" @default.

• next