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• W2068100688 abstract "Comorbidity studies have shown that depression and somatization (multiple somatoform symptoms) often overlap. Therefore it has been suggested to classify at least some patients with somatization syndromes under the category of depressive disorders. We wanted to investigate whether psychobiological investigations confirm the lumping of somatization and depression, or whether psychobiological pathways favor distinguishing these disorders. An overview is presented summarizing psychobiological studies including patients with depression and/or somatization-associated syndromes. We focus on the following topics: heritability, polymorphisms in special candidate genes, immune activation, hypothalamic-pituitary-adrenal (HPA) axis reactivity, serotonergic pathways, monoamino acids, and fatty acid concentrations. Immunological activation seems to be associated with specific features of somatoform disorders, namely, sickness behavior and pain thresholds. Genetic factors can also contribute to somatic complaints, e.g., via serotonergic pathways, HPA-axis response, immune activation, and other biological systems that contribute to the self-description of not being healthy. Some results indicate that psychobiological aspects of depression and somatization overlap in part (e.g., the relevance of serotonergic pathways), but there is clearly more evidence for discrepancies of psychobiological pathways in depression and somatization (e.g., the relevance of proinflammatory immune processes; HPA-axis activity; monoamino acid availability; omega-3-concentration; the role of triallelic subtypes of 5-HTTLPR). Many psychobiological pathways act differently in depression and somatization. These differences in psychobiology favor the distinction of these syndromes in classification approaches." @default.
• W2068100688 created "2016-06-24" @default.
• W2068100688 creator A5007098129 @default.
• W2068100688 creator A5058150182 @default.
• W2068100688 creator A5059409586 @default.
• W2068100688 creator A5061086957 @default.
• W2068100688 date "2010-05-01" @default.
• W2068100688 modified "2023-10-17" @default.
• W2068100688 title "Psychobiological differences between depression and somatization" @default.
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• W2068100688 doi "https://doi.org/10.1016/j.jpsychores.2010.02.001" @default.
• W2068100688 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20403510" @default.
• W2068100688 hasPublicationYear "2010" @default.
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