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- W2068100830 abstract "Currently available NSAIDs represent a heterogeneous group of therapeutic agents characterized by a variable benefit/risk profile. The development of a new class of selective COX-2 inhibitors, the coxibs, has contributed importantly to clarifying the discrete roles of COX-2 vs. COX-1 inhibition in different aspects of NSAID-related efficacy and safety. Cardiovascular toxicity has emerged as a previously unrecognized, mechanism-based effect of COX-2 inhibitors. Lessons learned from the many facets of the coxib failure story may help guiding the successful development of a new class of safer NSAIDs, targeting mediators unrelated to arachidonic acid metabolism or molecular targets downstream of COX-isozymes." @default.
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- W2068100830 date "2009-05-01" @default.
- W2068100830 modified "2023-10-16" @default.
- W2068100830 title "Nonsteroidal antiinflammatory drugs: Past, present and future☆" @default.
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- W2068100830 doi "https://doi.org/10.1016/j.phrs.2009.01.011" @default.
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