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- W2068103663 abstract "Evaluate the pharmacokinetics of two doses of a topical testosterone gel in surgically menopausal women. Prospective randomized study. Six bilaterally oophorectomized women (mean age 48.3; range 38–53) with agonadal serum free testosterone (T) levels (mean 1.28 pg/ml) were randomized to either 0.6 or 1.2 gm dose of a 1% T gel. Gel was applied daily to the outer thigh for 28 days. Five of the six women were on different estrogen therapies during the study. Volunteers were admitted to the hospital on days 1, 7 and 28 of T treatment and peripheral blood samples were obtained at -0.5, 0, 0.5, 1, 2, 3, 4, 6, 9, 12 and 24 hours after application. Serum levels of total T, free T, SHBG, estrone (E1) and estradiol (E2) were determined at each time point by radioimmunoassay. Area under the curve (AUC) for free T was calculated using the trapezoidal method. Free T levels achieved steady state in 3 women on application day 7 while the other volunteers continued to have increases in serum free T until day 28 regardless of the dose of T gel used. There was a wide range in AUCs among the volunteers (0.02–20.23 pg/ml). The one woman not on estrogen had the highest level of free T. Both E1 and E2 remained unchanged during the study while SHBG levels dropped. There is interindividual variation among women both in the amount and timing of T gel absorption. Dosing of supplemental T should be individualized using serum T levels. Concomitant estrogen therapy appears to decrease serum free T when using a transdermal T gel." @default.
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- W2068103663 date "2004-09-01" @default.
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- W2068103663 title "Pharmacokinetics of testosterone gel in bilaterally oophorectomized women" @default.
- W2068103663 doi "https://doi.org/10.1016/j.fertnstert.2004.07.173" @default.
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