FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068105844> ?p ?o ?g. }

• W2068105844 endingPage "676" @default.
• W2068105844 startingPage "668" @default.
• W2068105844 abstract "Metabolism of both carbamazepine (CBZ) and oxcarbazepine (OCBZ) were catalyzed by human liver microsomes and microsomes from livers of CBZ-induced or non-induced C57BL/6 mice. Human placental microsomes metabolized only OCBZ. Mouse liver microsomes metabolized CBZ to carbamazepine-10,11-epoxide (CBZ-E), 10-hydroxy-10,11-dihydro-carbamazepine (10-OH-CBZ), 3hydroxy-carbamazepine (3-OH-CBZ), 10,11-trans-dihydroxy-10,11-dihydro-carbamazepine (10,11-D) and to an unidentified metabolite. CBZ-pretreatment of mice increased both ethoxyresorufin O-deethylase activity in the liver and the amount of CBZ-E in microsomal incubations regardless of the age of mice. Human liver microsomes catalyzed the formation of CBZ to 9-hydroxymethyl-10-carbamoyl acridan (9-AC) in addition to CBZ-E, 3-OH-CBZ and 10-OH-CBZ. OCBZ was metabolized to its active metabolite in all incubations. An unknown metabolite was also present in some of the incubations. Human liver microsomes catalyzed only minute covalent binding of CBZ and OCBZ to DNA. Binding of OCBZ was, however, one order of magnitude greater than binding of CBZ. Human placental microsomes from the mothers on CBZ therapy did not catalyze CBZ metabolism. The same microsomes catalyzed OCBZ metabolism to 10-OH-CBZ and to an unknown metabolite. These results indicate autoinduction in CBZ metabolism in mouse liver. Due to the higher binding of OCBZ than CBZ to DNA in vitro, further studies on the potential mutagenicity of OCBZ may be warranted." @default.
• W2068105844 created "2016-06-24" @default.
• W2068105844 creator A5015580338 @default.
• W2068105844 creator A5044624793 @default.
• W2068105844 creator A5048995214 @default.
• W2068105844 creator A5073821263 @default.
• W2068105844 date "1998-12-01" @default.
• W2068105844 modified "2023-10-07" @default.
• W2068105844 title "Microsomal metabolism of carbamazepine and oxcarbazepine in liver and placenta" @default.
• W2068105844 cites W1520746198 @default.
• W2068105844 cites W1774580137 @default.
• W2068105844 cites W1898005997 @default.
• W2068105844 cites W1965335977 @default.
• W2068105844 cites W1976755012 @default.
• W2068105844 cites W2002474280 @default.
• W2068105844 cites W2005726890 @default.
• W2068105844 cites W2006112007 @default.
• W2068105844 cites W2011012699 @default.
• W2068105844 cites W2020557999 @default.
• W2068105844 cites W2049031381 @default.
• W2068105844 cites W2052628140 @default.
• W2068105844 cites W2053171587 @default.
• W2068105844 cites W2057467031 @default.
• W2068105844 cites W2062072547 @default.
• W2068105844 cites W2078784493 @default.
• W2068105844 cites W2079515082 @default.
• W2068105844 cites W2087706351 @default.
• W2068105844 cites W2094975151 @default.
• W2068105844 cites W2135068732 @default.
• W2068105844 cites W2152068775 @default.
• W2068105844 cites W2037488300 @default.
• W2068105844 doi "https://doi.org/10.1177/096032719801701204" @default.
• W2068105844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9988371" @default.
• W2068105844 hasPublicationYear "1998" @default.
• W2068105844 type Work @default.
• W2068105844 sameAs 2068105844 @default.
• W2068105844 citedByCount "22" @default.
• W2068105844 countsByYear W20681058442012 @default.
• W2068105844 countsByYear W20681058442014 @default.
• W2068105844 countsByYear W20681058442016 @default.
• W2068105844 countsByYear W20681058442018 @default.
• W2068105844 countsByYear W20681058442019 @default.
• W2068105844 countsByYear W20681058442020 @default.
• W2068105844 countsByYear W20681058442022 @default.
• W2068105844 crossrefType "journal-article" @default.
• W2068105844 hasAuthorship W2068105844A5015580338 @default.
• W2068105844 hasAuthorship W2068105844A5044624793 @default.
• W2068105844 hasAuthorship W2068105844A5048995214 @default.
• W2068105844 hasAuthorship W2068105844A5073821263 @default.
• W2068105844 hasConcept C169760540 @default.
• W2068105844 hasConcept C185592680 @default.
• W2068105844 hasConcept C202751555 @default.
• W2068105844 hasConcept C2775858608 @default.
• W2068105844 hasConcept C2776524530 @default.
• W2068105844 hasConcept C2777477808 @default.
• W2068105844 hasConcept C2778186239 @default.
• W2068105844 hasConcept C2779253243 @default.
• W2068105844 hasConcept C2781176495 @default.
• W2068105844 hasConcept C55493867 @default.
• W2068105844 hasConcept C62231903 @default.
• W2068105844 hasConcept C86803240 @default.
• W2068105844 hasConcept C87644729 @default.
• W2068105844 hasConcept C89311334 @default.
• W2068105844 hasConcept C98274493 @default.
• W2068105844 hasConceptScore W2068105844C169760540 @default.
• W2068105844 hasConceptScore W2068105844C185592680 @default.
• W2068105844 hasConceptScore W2068105844C202751555 @default.
• W2068105844 hasConceptScore W2068105844C2775858608 @default.
• W2068105844 hasConceptScore W2068105844C2776524530 @default.
• W2068105844 hasConceptScore W2068105844C2777477808 @default.
• W2068105844 hasConceptScore W2068105844C2778186239 @default.
• W2068105844 hasConceptScore W2068105844C2779253243 @default.
• W2068105844 hasConceptScore W2068105844C2781176495 @default.
• W2068105844 hasConceptScore W2068105844C55493867 @default.
• W2068105844 hasConceptScore W2068105844C62231903 @default.
• W2068105844 hasConceptScore W2068105844C86803240 @default.
• W2068105844 hasConceptScore W2068105844C87644729 @default.
• W2068105844 hasConceptScore W2068105844C89311334 @default.
• W2068105844 hasConceptScore W2068105844C98274493 @default.
• W2068105844 hasIssue "12" @default.
• W2068105844 hasLocation W20681058441 @default.
• W2068105844 hasLocation W20681058442 @default.
• W2068105844 hasOpenAccess W2068105844 @default.
• W2068105844 hasPrimaryLocation W20681058441 @default.
• W2068105844 hasRelatedWork W1974093283 @default.
• W2068105844 hasRelatedWork W2016354756 @default.
• W2068105844 hasRelatedWork W2099311188 @default.
• W2068105844 hasRelatedWork W2120839582 @default.
• W2068105844 hasRelatedWork W2271852504 @default.
• W2068105844 hasRelatedWork W2350644169 @default.
• W2068105844 hasRelatedWork W2353241900 @default.
• W2068105844 hasRelatedWork W2377043717 @default.
• W2068105844 hasRelatedWork W2807966868 @default.
• W2068105844 hasRelatedWork W3216809230 @default.
• W2068105844 hasVolume "17" @default.
• W2068105844 isParatext "false" @default.
• W2068105844 isRetracted "false" @default.
• W2068105844 magId "2068105844" @default.

• next