Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068110537> ?p ?o ?g. }
- W2068110537 endingPage "1679" @default.
- W2068110537 startingPage "1671" @default.
- W2068110537 abstract "The majority of neurodegenerative diseases have an important age component, and thus, understanding the molecular changes that occur during normal aging of the brain is of utmost relevance. In search for the basis of the age-related cognitive decline found in humans, monkeys and rodents, we study the rhesus monkey. Surprisingly, there is no loss of neurons in aged monkey brains. However, we reported white matter and myelin abnormalities in aged monkeys, similar to those observed in Alzheimer’s disease and multiple sclerosis patients. In a microarray analysis comparing young and old monkey white matter, we discovered that Klotho is downregulated in the aged brain. We then asked whether there is a connection between the age-related cognitive decline, myelin abnormalities and Klotho downregulation. If such a connection is found, compounds that upregulate Klotho expression could become of therapeutic interest for the treatment of multiple sclerosis, and perhaps even Alzheimer’s disease." @default.
- W2068110537 created "2016-06-24" @default.
- W2068110537 creator A5012268693 @default.
- W2068110537 creator A5012372114 @default.
- W2068110537 creator A5052419811 @default.
- W2068110537 creator A5055567926 @default.
- W2068110537 creator A5062185738 @default.
- W2068110537 date "2012-09-01" @default.
- W2068110537 modified "2023-10-18" @default.
- W2068110537 title "Small-molecule Klotho enhancers as novel treatment of neurodegeneration" @default.
- W2068110537 cites W1504986323 @default.
- W2068110537 cites W1534176032 @default.
- W2068110537 cites W1679008590 @default.
- W2068110537 cites W1866034006 @default.
- W2068110537 cites W1964460240 @default.
- W2068110537 cites W1971870160 @default.
- W2068110537 cites W1982643425 @default.
- W2068110537 cites W1983527841 @default.
- W2068110537 cites W1985860523 @default.
- W2068110537 cites W1989215707 @default.
- W2068110537 cites W1990789850 @default.
- W2068110537 cites W2001750225 @default.
- W2068110537 cites W2024826247 @default.
- W2068110537 cites W2028480953 @default.
- W2068110537 cites W2032689615 @default.
- W2068110537 cites W2038757125 @default.
- W2068110537 cites W2044542883 @default.
- W2068110537 cites W2045867494 @default.
- W2068110537 cites W2047281885 @default.
- W2068110537 cites W2049229440 @default.
- W2068110537 cites W2050565170 @default.
- W2068110537 cites W2057789602 @default.
- W2068110537 cites W2058358434 @default.
- W2068110537 cites W2058718560 @default.
- W2068110537 cites W2072645006 @default.
- W2068110537 cites W2076538842 @default.
- W2068110537 cites W2087544898 @default.
- W2068110537 cites W2091948921 @default.
- W2068110537 cites W2094148720 @default.
- W2068110537 cites W2102244214 @default.
- W2068110537 cites W2106711282 @default.
- W2068110537 cites W2110872223 @default.
- W2068110537 cites W2114360920 @default.
- W2068110537 cites W2120126332 @default.
- W2068110537 cites W2120129493 @default.
- W2068110537 cites W2120684638 @default.
- W2068110537 cites W2123223518 @default.
- W2068110537 cites W2132537604 @default.
- W2068110537 cites W2137720344 @default.
- W2068110537 cites W2142938720 @default.
- W2068110537 cites W2151588047 @default.
- W2068110537 cites W2157669984 @default.
- W2068110537 cites W2166843798 @default.
- W2068110537 cites W4210952460 @default.
- W2068110537 cites W4235689530 @default.
- W2068110537 doi "https://doi.org/10.4155/fmc.12.134" @default.
- W2068110537 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3564652" @default.
- W2068110537 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22924505" @default.
- W2068110537 hasPublicationYear "2012" @default.
- W2068110537 type Work @default.
- W2068110537 sameAs 2068110537 @default.
- W2068110537 citedByCount "51" @default.
- W2068110537 countsByYear W20681105372012 @default.
- W2068110537 countsByYear W20681105372013 @default.
- W2068110537 countsByYear W20681105372014 @default.
- W2068110537 countsByYear W20681105372015 @default.
- W2068110537 countsByYear W20681105372016 @default.
- W2068110537 countsByYear W20681105372017 @default.
- W2068110537 countsByYear W20681105372018 @default.
- W2068110537 countsByYear W20681105372019 @default.
- W2068110537 countsByYear W20681105372020 @default.
- W2068110537 countsByYear W20681105372021 @default.
- W2068110537 countsByYear W20681105372022 @default.
- W2068110537 countsByYear W20681105372023 @default.
- W2068110537 crossrefType "journal-article" @default.
- W2068110537 hasAuthorship W2068110537A5012268693 @default.
- W2068110537 hasAuthorship W2068110537A5012372114 @default.
- W2068110537 hasAuthorship W2068110537A5052419811 @default.
- W2068110537 hasAuthorship W2068110537A5055567926 @default.
- W2068110537 hasAuthorship W2068110537A5062185738 @default.
- W2068110537 hasBestOaLocation W20681105372 @default.
- W2068110537 hasConcept C104317684 @default.
- W2068110537 hasConcept C126322002 @default.
- W2068110537 hasConcept C126838900 @default.
- W2068110537 hasConcept C127561419 @default.
- W2068110537 hasConcept C142724271 @default.
- W2068110537 hasConcept C143409427 @default.
- W2068110537 hasConcept C15744967 @default.
- W2068110537 hasConcept C169760540 @default.
- W2068110537 hasConcept C203014093 @default.
- W2068110537 hasConcept C2776925932 @default.
- W2068110537 hasConcept C2778609137 @default.
- W2068110537 hasConcept C2779134260 @default.
- W2068110537 hasConcept C2779483572 @default.
- W2068110537 hasConcept C2780091579 @default.
- W2068110537 hasConcept C2780640218 @default.
- W2068110537 hasConcept C2781192897 @default.
- W2068110537 hasConcept C2984863031 @default.