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- W2068114310 abstract "We have examined the growth of ganglion cell somas during development of the cat's retina. Until approximately E (embryonic day) 50, ganglion cell somas show no sign of the several variations in their size apparent in the adult. At about E50, the somas begin to accumulate granular cytoplasm. The accumulation proceeds first among area centralis cells which, for a few days, are the largest ganglion cells in the retina (whereas in the adult they are the smallest). By E57 three of the adult soma size trends have become apparent: the differentiation of soma size related to functional class, the nasal-temporal difference in soma size, and the small mean size of somas in the visual streak. The early appearance of these trends in soma size suggests that individual cells may be intrinsically programmed to develop as cells of a particular class, such as alpha-, beta-, or gamma-cells, even before their morphological differentiation begins. A fourth trend in soma size, the centro-peripheral difference, appears only after an initial period of ganglion cell growth; the small size of ganglion cells at the area centralis seems to be determined, at least partly, by a local “environmental” factor, the crowding of ganglion cells." @default.
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- W2068114310 date "1983-11-20" @default.
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- W2068114310 title "Time course of morphological differentiation of cat retinal ganglion cells: Influences on soma size" @default.
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- W2068114310 doi "https://doi.org/10.1002/cne.902210104" @default.
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