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- W2068117114 abstract "A new proviral integration site for feline leukemia virus (FeLV), termed flit -1, was identified from feline thymic lymphoma. Among 35 FeLV-related tumors examined, 5 of 25 thymic lymphomas demonstrated proviral insertion within flit -1 locus whereas none of four alimentary and five multicentric lymphomas and one T-lymphoid leukemia examined had rearrangement in this region. Extensive sequence analysis has shown that flit -1, which is noncoding, is conserved on human chromosome 12 and mouse chromosome 15. The human and murine homologs of flit -1 are positioned approximately 30-kb upstream to activin-A receptor type II-like 1 ( ACVRL1/ALK1 ) gene. Expression of ACVRL1 mRNA was examined in two of five lymphomas with flit -1 rearrangement and detected in both of the two whereas normal thymuses and seven lymphoid tumors without flit -1 rearrangement had no detectable expression. Therefore, flit -1 appears to represent a novel FeLV proviral common integration domain that may influence lymphomagenesis as insertional mutagenesis." @default.
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- W2068117114 date "2009-03-01" @default.
- W2068117114 modified "2023-10-04" @default.
- W2068117114 title "Identification of a novel common proviral integration site, flit-1, in feline leukemia virus induced thymic lymphoma" @default.
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- W2068117114 doi "https://doi.org/10.1016/j.virol.2009.01.021" @default.
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