Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068118831> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2068118831 endingPage "S826" @default.
- W2068118831 startingPage "S825" @default.
- W2068118831 abstract "To evaluate the feasibility of CyberKnife (CK) partial breast irradiation (PBI) delivery for early stage breast cancer, and to compare target coverage and organ at risk (OAR) dose of 3D conformal radiation therapy (3DCRT) planning techniques with the CK system. Ten patients (pts) were selected with early stage breast cancer who had clearly delineated lumpectomy cavities and were candidates for PBI using the eligibility criteria of the current ongoing phase III trial evaluating PBI (RTOG 0413/NSABP B-39). Pts were re-planned to a dose of 34 Gy in 10 fractions with both 3DCRT and CK. The lumpectomy cavity was contoured and expanded by 15 mm and reduced appropriately from the skin and chest wall to constitute the CTV. No PTV margin was added for this comparison. 3DCRT treatment plans were generated using 4-5 noncoplanar beams typically with 3 medial tangential beams and 1 lateral tangential beam with conformal blocks directed at the CTV. Plans were optimized to achieve optimal CTV coverage while minimizing organ at risk (OAR) doses to at least those consistent with the requirements stated on RTOG 0413, and plans were typically prescribed to 95-100%. For CK, inverse planning with specific dosimetric objectives was performed. One to two collimators were used to provide highly conformal dose distributions, and plans were typically prescribed to the 70-80% isodose line. Dose volume analysis for various endpoints was performed and comparative analysis was done using SAS (Cary, NC). A total of 20 PBI breast plans (10 CK and 10 3DCRT) were generated, 12 left and 8 right breast plans, and were evaluated for CTV coverage and OAR dose-volume criteria of interest. Median CTV coverage (V100%) for CK and 3DCRT was 98% (range, 98-100%) and 95% (90-100%) respectively (p = 0.03). Median V15% to the ipsilateral lung was 3% (0-6%) for CK and 4% (0-14%) for 3DCRT (p = 0.02). Median maximum point dose to the heart was 1.3 Gy (0.5-17) for CK and 7.8 Gy (0.8-33.7) for 3DCRT (p = 0.003). Median volume of ipsilateral breast receiving the prescription dose (V100%) was 13% (4-24) for CK and 22% (4-28) for 3DCRT (p = 0.004). V50% for the ipsilateral breast was 40% and 51% for CK and 3DCRT respectively (p = 0.003). Median maximum dose to the skin was 35.1 Gy (29.8-38.8) for CK and 32.1 Gy (29.9-37.9) for 3DCRT (p = 0.06). CK treatment planning for PBI is feasible to achieve conformal target coverage while significantly reducing dose to OARs compared to 3DCRT planning. When the advantages of CK to account for target motion and setup error are considered, CK would even further reduce dose to OARs. Reduction in dose to the normal breast seen with the CK system may translate into better cosmetic outcomes and is currently being evaluated in a phase I trial at our institution." @default.
- W2068118831 created "2016-06-24" @default.
- W2068118831 creator A5024671529 @default.
- W2068118831 creator A5029218639 @default.
- W2068118831 creator A5033395766 @default.
- W2068118831 creator A5042349377 @default.
- W2068118831 creator A5053960294 @default.
- W2068118831 creator A5055991332 @default.
- W2068118831 creator A5059155662 @default.
- W2068118831 creator A5068359755 @default.
- W2068118831 creator A5083376265 @default.
- W2068118831 creator A5084995762 @default.
- W2068118831 date "2010-11-01" @default.
- W2068118831 modified "2023-09-26" @default.
- W2068118831 title "Comparative Dose-Volume Analysis for CyberKnife and 3D Conformal Partial Breast Irradiation Treatment of Early Stage Breast Cancer" @default.
- W2068118831 doi "https://doi.org/10.1016/j.ijrobp.2010.07.1911" @default.
- W2068118831 hasPublicationYear "2010" @default.
- W2068118831 type Work @default.
- W2068118831 sameAs 2068118831 @default.
- W2068118831 citedByCount "11" @default.
- W2068118831 countsByYear W20681188312012 @default.
- W2068118831 countsByYear W20681188312014 @default.
- W2068118831 countsByYear W20681188312015 @default.
- W2068118831 countsByYear W20681188312016 @default.
- W2068118831 countsByYear W20681188312017 @default.
- W2068118831 countsByYear W20681188312018 @default.
- W2068118831 countsByYear W20681188312021 @default.
- W2068118831 crossrefType "journal-article" @default.
- W2068118831 hasAuthorship W2068118831A5024671529 @default.
- W2068118831 hasAuthorship W2068118831A5029218639 @default.
- W2068118831 hasAuthorship W2068118831A5033395766 @default.
- W2068118831 hasAuthorship W2068118831A5042349377 @default.
- W2068118831 hasAuthorship W2068118831A5053960294 @default.
- W2068118831 hasAuthorship W2068118831A5055991332 @default.
- W2068118831 hasAuthorship W2068118831A5059155662 @default.
- W2068118831 hasAuthorship W2068118831A5068359755 @default.
- W2068118831 hasAuthorship W2068118831A5083376265 @default.
- W2068118831 hasAuthorship W2068118831A5084995762 @default.
- W2068118831 hasBestOaLocation W20681188311 @default.
- W2068118831 hasConcept C121608353 @default.
- W2068118831 hasConcept C126322002 @default.
- W2068118831 hasConcept C126838900 @default.
- W2068118831 hasConcept C146357865 @default.
- W2068118831 hasConcept C151730666 @default.
- W2068118831 hasConcept C201645570 @default.
- W2068118831 hasConcept C2776651944 @default.
- W2068118831 hasConcept C2777757722 @default.
- W2068118831 hasConcept C2779572924 @default.
- W2068118831 hasConcept C2780387249 @default.
- W2068118831 hasConcept C2989005 @default.
- W2068118831 hasConcept C509974204 @default.
- W2068118831 hasConcept C530470458 @default.
- W2068118831 hasConcept C71924100 @default.
- W2068118831 hasConcept C86803240 @default.
- W2068118831 hasConceptScore W2068118831C121608353 @default.
- W2068118831 hasConceptScore W2068118831C126322002 @default.
- W2068118831 hasConceptScore W2068118831C126838900 @default.
- W2068118831 hasConceptScore W2068118831C146357865 @default.
- W2068118831 hasConceptScore W2068118831C151730666 @default.
- W2068118831 hasConceptScore W2068118831C201645570 @default.
- W2068118831 hasConceptScore W2068118831C2776651944 @default.
- W2068118831 hasConceptScore W2068118831C2777757722 @default.
- W2068118831 hasConceptScore W2068118831C2779572924 @default.
- W2068118831 hasConceptScore W2068118831C2780387249 @default.
- W2068118831 hasConceptScore W2068118831C2989005 @default.
- W2068118831 hasConceptScore W2068118831C509974204 @default.
- W2068118831 hasConceptScore W2068118831C530470458 @default.
- W2068118831 hasConceptScore W2068118831C71924100 @default.
- W2068118831 hasConceptScore W2068118831C86803240 @default.
- W2068118831 hasIssue "3" @default.
- W2068118831 hasLocation W20681188311 @default.
- W2068118831 hasOpenAccess W2068118831 @default.
- W2068118831 hasPrimaryLocation W20681188311 @default.
- W2068118831 hasRelatedWork W1979397005 @default.
- W2068118831 hasRelatedWork W2032769033 @default.
- W2068118831 hasRelatedWork W2046122576 @default.
- W2068118831 hasRelatedWork W2063809657 @default.
- W2068118831 hasRelatedWork W2065510198 @default.
- W2068118831 hasRelatedWork W2100939674 @default.
- W2068118831 hasRelatedWork W2265958940 @default.
- W2068118831 hasRelatedWork W2466963043 @default.
- W2068118831 hasRelatedWork W4236693431 @default.
- W2068118831 hasRelatedWork W4309713310 @default.
- W2068118831 hasVolume "78" @default.
- W2068118831 isParatext "false" @default.
- W2068118831 isRetracted "false" @default.
- W2068118831 magId "2068118831" @default.
- W2068118831 workType "article" @default.