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- W2068124306 abstract "9-cis-Retinoic acid and 9, 13-di-cis-retinoic acid were synthesized and their biological effects on human acute promyelocytic cell line HL-60 were analyzed. 9-cis-Retinoic acid was threefold more potent than all-trans-retinoic acid in assays to inhibit growth and to induce differentiation of HL-60 cells. The activity of 9, 13-di-cis-retinoic acid was as high as that of all-trans-retinoic acid. Both 9-cis-retinoic acid and 9, 13-di-cis-retinoic acid acted additively with all-trans-retinc is acid on HL-60 cells. Both 9-cis-retinoic acid and 9, 13-di-cis-retinoic acid acted synergetirally with 1α, 25-dihydroxyvitamin D3 to inhibit HL-60 cell proliferation. Thyroid hormone (T3) did not affect the action of the retinoids on HL-60 cells." @default.
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- W2068124306 date "1993-01-01" @default.
- W2068124306 modified "2023-09-27" @default.
- W2068124306 title "Biological Effect of 9-cis-Retinoic Acid and 9,13-di-cis-Retinoic Acid on Human Acute Promyelocytic Leukemia Cell Line HL-60." @default.
- W2068124306 doi "https://doi.org/10.2183/pjab.69.185" @default.
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