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• W2068124661 abstract "High mobility group (HMG) I-type chromosomal phosphoproteins HMG I/Y and HMG I-C were investigated following morphine treatment of C6BU-1 glioma. Cells were labelled with [32P]-orthophosphoric acid. Electrophoretic profiles and autoradiograms of the control cells revealed the presence of HMG I and HMG I-C proteins. HMG Y was not detected. Northern blot analysis showed a single HMG I/Y transcript. Treatment with morphine lowered the [32P]-incorporation in HMG I and HMGI-C proteins and the level of the HMG I/Y transcript. However, it did not change the protein ratios on the Coomassie stained gels. These results suggest that morphine may trigger independent reaction pathways affecting either transcription regulation and/or postsynthetic phosphorylation of the preexisting HMG I-type proteins. In addition, opposing changes in the postsynthetic phosphorylation of HMG 14 and histones HI AB were also noticed." @default.
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• W2068124661 date "2000-03-01" @default.
• W2068124661 modified "2023-10-18" @default.
• W2068124661 title "Morphine treatment affects the regulation of high mobility group I-type chromosomal phosphoproteevs in C6 glioma cells" @default.
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• W2068124661 doi "https://doi.org/10.1016/s0024-3205(00)00495-1" @default.
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