FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068125466> ?p ?o ?g. }

• W2068125466 endingPage "417" @default.
• W2068125466 startingPage "414" @default.
• W2068125466 abstract "Neuregulins signal cells by binding to an activating hetero- and homodimeric forms of the neuregulin receptors HER2 (erbB2), HER3 (erbB3), and HER4 (erbB4). Axonally derived neuregulin signals myelin forming cells of the central and peripheral nervous systems through different receptor complexes: oligodendrocytes through erbB2/erbB4 heterodimers and Schwann cells through erbB2/erbB3 heterodimers. Since the leading edge of myelinating cells interacts directly with the axonal surface, we were interested in determining if signaling molecules localized at the leading edge associate with activated neuregulin receptors. We found a novel association between neuregulin receptors and focal adhesion kinase (FAK) in primary cultures of Schwann cells. Following stimulation with ligand, maximal binding of FAK to HER2 occurred by 1 min whereas maximal binding to HER3 was delayed to approximately 7 min. FAK is localized in focal adhesions of Schwann cells. We have previously shown HER2 and HER3 are distributed evenly throughout the plasmalemma. Neuregulins thus use FAK to transmit intracellular signals and the differential kinetics of FAK association with individual neuregulin receptors, as well as its restricted subcellular localization, may play a role in specifying biologic responses." @default.
• W2068125466 created "2016-06-24" @default.
• W2068125466 creator A5016269402 @default.
• W2068125466 creator A5020688057 @default.
• W2068125466 creator A5035008437 @default.
• W2068125466 creator A5039163206 @default.
• W2068125466 creator A5068705235 @default.
• W2068125466 date "2000-05-01" @default.
• W2068125466 modified "2023-09-25" @default.
• W2068125466 title "Neuregulin Induces the Rapid Association of Focal Adhesion Kinase with the erbB2–erbB3 Receptor Complex in Schwann Cells" @default.
• W2068125466 cites W1604121661 @default.
• W2068125466 cites W1977333251 @default.
• W2068125466 cites W1980141913 @default.
• W2068125466 cites W1984734582 @default.
• W2068125466 cites W1987659834 @default.
• W2068125466 cites W1998759184 @default.
• W2068125466 cites W2004813091 @default.
• W2068125466 cites W2012828388 @default.
• W2068125466 cites W2047909489 @default.
• W2068125466 cites W2057158750 @default.
• W2068125466 cites W2057698056 @default.
• W2068125466 cites W2087663072 @default.
• W2068125466 cites W2094895636 @default.
• W2068125466 cites W2102718676 @default.
• W2068125466 cites W2115113861 @default.
• W2068125466 cites W2115940913 @default.
• W2068125466 cites W2126087366 @default.
• W2068125466 cites W2128133606 @default.
• W2068125466 cites W2154904429 @default.
• W2068125466 cites W2158330548 @default.
• W2068125466 cites W2162288195 @default.
• W2068125466 doi "https://doi.org/10.1006/bbrc.2000.2624" @default.
• W2068125466 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10799311" @default.
• W2068125466 hasPublicationYear "2000" @default.
• W2068125466 type Work @default.
• W2068125466 sameAs 2068125466 @default.
• W2068125466 citedByCount "37" @default.
• W2068125466 countsByYear W20681254662012 @default.
• W2068125466 countsByYear W20681254662013 @default.
• W2068125466 countsByYear W20681254662014 @default.
• W2068125466 countsByYear W20681254662015 @default.
• W2068125466 countsByYear W20681254662018 @default.
• W2068125466 countsByYear W20681254662019 @default.
• W2068125466 countsByYear W20681254662021 @default.
• W2068125466 crossrefType "journal-article" @default.
• W2068125466 hasAuthorship W2068125466A5016269402 @default.
• W2068125466 hasAuthorship W2068125466A5020688057 @default.
• W2068125466 hasAuthorship W2068125466A5035008437 @default.
• W2068125466 hasAuthorship W2068125466A5039163206 @default.
• W2068125466 hasAuthorship W2068125466A5068705235 @default.
• W2068125466 hasConcept C101544691 @default.
• W2068125466 hasConcept C108391706 @default.
• W2068125466 hasConcept C115456853 @default.
• W2068125466 hasConcept C151166631 @default.
• W2068125466 hasConcept C169760540 @default.
• W2068125466 hasConcept C170493617 @default.
• W2068125466 hasConcept C184235292 @default.
• W2068125466 hasConcept C185323287 @default.
• W2068125466 hasConcept C185592680 @default.
• W2068125466 hasConcept C2778560701 @default.
• W2068125466 hasConcept C2778609137 @default.
• W2068125466 hasConcept C2779251935 @default.
• W2068125466 hasConcept C2780943970 @default.
• W2068125466 hasConcept C529278444 @default.
• W2068125466 hasConcept C55493867 @default.
• W2068125466 hasConcept C62478195 @default.
• W2068125466 hasConcept C86803240 @default.
• W2068125466 hasConcept C90934575 @default.
• W2068125466 hasConcept C95444343 @default.
• W2068125466 hasConcept C97029542 @default.
• W2068125466 hasConceptScore W2068125466C101544691 @default.
• W2068125466 hasConceptScore W2068125466C108391706 @default.
• W2068125466 hasConceptScore W2068125466C115456853 @default.
• W2068125466 hasConceptScore W2068125466C151166631 @default.
• W2068125466 hasConceptScore W2068125466C169760540 @default.
• W2068125466 hasConceptScore W2068125466C170493617 @default.
• W2068125466 hasConceptScore W2068125466C184235292 @default.
• W2068125466 hasConceptScore W2068125466C185323287 @default.
• W2068125466 hasConceptScore W2068125466C185592680 @default.
• W2068125466 hasConceptScore W2068125466C2778560701 @default.
• W2068125466 hasConceptScore W2068125466C2778609137 @default.
• W2068125466 hasConceptScore W2068125466C2779251935 @default.
• W2068125466 hasConceptScore W2068125466C2780943970 @default.
• W2068125466 hasConceptScore W2068125466C529278444 @default.
• W2068125466 hasConceptScore W2068125466C55493867 @default.
• W2068125466 hasConceptScore W2068125466C62478195 @default.
• W2068125466 hasConceptScore W2068125466C86803240 @default.
• W2068125466 hasConceptScore W2068125466C90934575 @default.
• W2068125466 hasConceptScore W2068125466C95444343 @default.
• W2068125466 hasConceptScore W2068125466C97029542 @default.
• W2068125466 hasIssue "2" @default.
• W2068125466 hasLocation W20681254661 @default.
• W2068125466 hasLocation W20681254662 @default.
• W2068125466 hasOpenAccess W2068125466 @default.
• W2068125466 hasPrimaryLocation W20681254661 @default.
• W2068125466 hasRelatedWork W1970446746 @default.
• W2068125466 hasRelatedWork W1970893866 @default.
• W2068125466 hasRelatedWork W2013561277 @default.

• next