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- W2068125835 endingPage "469" @default.
- W2068125835 startingPage "457" @default.
- W2068125835 abstract "Perlecan is a ubiquitous proteoglycan of basement membrane and vascularized tissues but is also present in articular cartilage, meniscus and intervertebral disc, which are devoid of basement membrane and predominantly avascular. It is a prominent pericellular proteoglycan in the transitory matrix of the cartilaginous rudiments that develop into components of diarthrodial joints and the axial skeleton, and it forms intricate perichondrial vessel networks that define the presumptive articulating surfaces of developing joints and line the cartilage canals in cartilaginous rudiments. Such vessels have roles in the nutrition of the expanding cell numbers in the developing joint. Perlecan sequesters a number of growth factors pericellularly (FGFs, PDGF, VEGF and CTGF) and through these promotes cell signalling, cell proliferation and differentiation. Perlecan also interacts with a diverse range of extracellular matrix proteins, stabilising and organising the ECM, and promoting collagen fibrillogenesis. Perlecan is a prominent pericellular component of mesenchymal cells from their earliest developmental stages through to maturation, forming cell–cell and cell–ECM interconnections that are suggestive of a role in mechanosensory processes important to tissue homeostasis. BioEssays 30:457–469, 2008. © 2008 Wiley Periodicals, Inc." @default.
- W2068125835 created "2016-06-24" @default.
- W2068125835 creator A5023553044 @default.
- W2068125835 creator A5024041758 @default.
- W2068125835 creator A5061677318 @default.
- W2068125835 creator A5076112559 @default.
- W2068125835 date "2008-01-01" @default.
- W2068125835 modified "2023-10-09" @default.
- W2068125835 title "Perlecan, the “jack of all trades” proteoglycan of cartilaginous weight-bearing connective tissues" @default.
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