FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068131808> ?p ?o ?g. }

• W2068131808 endingPage "5597" @default.
• W2068131808 startingPage "5591" @default.
• W2068131808 abstract "Effectors involved in G protein-coupled receptor signaling modulate activity of GTPases through GTPase-activating protein or guanine nucleotide exchanging factor (GEF). Phospholipase Cδ1 (PLCδ1) is an effector in tissue transglutaminase (TGII)-mediated α_1B-adrenoreceptor (α_1BAR) signaling. We investigated whether PLCδ1 modulates TGII activity. PLCδ1 stimulated GDP release from TGII in a concentration-dependent manner, resulting in an increase in GTPγS binding to TGII. PLCδ1 also inhibited GTP hydrolysis by TGII that was independent from the α_1BAR. These results indicate that PLCδ1 is GEF for TGII and stabilizes the GTP·TGII complex. When GEF function of PLCδ1 was compared with that of the α_1BAR, the α_1BAR-mediated GTPγS binding to TGII was greater than PLCδ1-mediated binding and was accelerated in the presence of PLCδ1. Thus, the α_1BAR is the prime GEF for TGII, and GEF activity of PLCδ1 promotes coupling efficacy of this signaling system. Overexpression of TGII and its mutants with and without PLCδ1 resulted in an increase in α_1BAR-stimulated Ca²⁺ release from intracellular stores in a TGII-specific manner. We conclude that PLCδ1 assists the α_1BAR function through its GEF action and is primarily activated by the coupling of TGII to the cognate receptors." @default.
• W2068131808 created "2016-06-24" @default.
• W2068131808 creator A5006677281 @default.
• W2068131808 creator A5028584423 @default.
• W2068131808 creator A5044196607 @default.
• W2068131808 creator A5090556368 @default.
• W2068131808 date "2001-02-01" @default.
• W2068131808 modified "2023-10-11" @default.
• W2068131808 title "Phospholipase Cδ1 Is a Guanine Nucleotide Exchanging Factor for Transglutaminase II (Gαh) and Promotes α1B-Adrenoreceptor-mediated GTP Binding and Intracellular Calcium Release" @default.
• W2068131808 cites W1503425505 @default.
• W2068131808 cites W1503629275 @default.
• W2068131808 cites W1509677149 @default.
• W2068131808 cites W1514968181 @default.
• W2068131808 cites W1529192632 @default.
• W2068131808 cites W1558700872 @default.
• W2068131808 cites W1582659466 @default.
• W2068131808 cites W1592181599 @default.
• W2068131808 cites W1606090338 @default.
• W2068131808 cites W1841743894 @default.
• W2068131808 cites W1960199343 @default.
• W2068131808 cites W1981182586 @default.
• W2068131808 cites W1981715774 @default.
• W2068131808 cites W1986861517 @default.
• W2068131808 cites W1988867634 @default.
• W2068131808 cites W1997784032 @default.
• W2068131808 cites W1999453187 @default.
• W2068131808 cites W1999466305 @default.
• W2068131808 cites W2011915496 @default.
• W2068131808 cites W2017364006 @default.
• W2068131808 cites W2019340689 @default.
• W2068131808 cites W2033653650 @default.
• W2068131808 cites W2035633569 @default.
• W2068131808 cites W2045255717 @default.
• W2068131808 cites W2050307742 @default.
• W2068131808 cites W2054577756 @default.
• W2068131808 cites W2059154200 @default.
• W2068131808 cites W2061413318 @default.
• W2068131808 cites W2063708626 @default.
• W2068131808 cites W2065792676 @default.
• W2068131808 cites W2070524237 @default.
• W2068131808 cites W2077231895 @default.
• W2068131808 cites W2087953477 @default.
• W2068131808 cites W2092975281 @default.
• W2068131808 cites W2113177481 @default.
• W2068131808 cites W2118656164 @default.
• W2068131808 cites W2119889843 @default.
• W2068131808 cites W2141260882 @default.
• W2068131808 cites W2189033227 @default.
• W2068131808 cites W2223734153 @default.
• W2068131808 doi "https://doi.org/10.1074/jbc.m008252200" @default.
• W2068131808 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11087745" @default.
• W2068131808 hasPublicationYear "2001" @default.
• W2068131808 type Work @default.
• W2068131808 sameAs 2068131808 @default.
• W2068131808 citedByCount "59" @default.
• W2068131808 countsByYear W20681318082012 @default.
• W2068131808 countsByYear W20681318082013 @default.
• W2068131808 countsByYear W20681318082014 @default.
• W2068131808 countsByYear W20681318082015 @default.
• W2068131808 countsByYear W20681318082017 @default.
• W2068131808 countsByYear W20681318082020 @default.
• W2068131808 countsByYear W20681318082021 @default.
• W2068131808 countsByYear W20681318082022 @default.
• W2068131808 countsByYear W20681318082023 @default.
• W2068131808 crossrefType "journal-article" @default.
• W2068131808 hasAuthorship W2068131808A5006677281 @default.
• W2068131808 hasAuthorship W2068131808A5028584423 @default.
• W2068131808 hasAuthorship W2068131808A5044196607 @default.
• W2068131808 hasAuthorship W2068131808A5090556368 @default.
• W2068131808 hasBestOaLocation W20681318081 @default.
• W2068131808 hasConcept C104317684 @default.
• W2068131808 hasConcept C118716 @default.
• W2068131808 hasConcept C126619667 @default.
• W2068131808 hasConcept C12927208 @default.
• W2068131808 hasConcept C163181125 @default.
• W2068131808 hasConcept C178498320 @default.
• W2068131808 hasConcept C181199279 @default.
• W2068131808 hasConcept C185592680 @default.
• W2068131808 hasConcept C207332259 @default.
• W2068131808 hasConcept C2778597717 @default.
• W2068131808 hasConcept C512185932 @default.
• W2068131808 hasConcept C51785407 @default.
• W2068131808 hasConcept C55493867 @default.
• W2068131808 hasConcept C62478195 @default.
• W2068131808 hasConcept C66135807 @default.
• W2068131808 hasConcept C79879829 @default.
• W2068131808 hasConcept C80631254 @default.
• W2068131808 hasConcept C85771745 @default.
• W2068131808 hasConcept C86803240 @default.
• W2068131808 hasConcept C95444343 @default.
• W2068131808 hasConceptScore W2068131808C104317684 @default.
• W2068131808 hasConceptScore W2068131808C118716 @default.
• W2068131808 hasConceptScore W2068131808C126619667 @default.
• W2068131808 hasConceptScore W2068131808C12927208 @default.
• W2068131808 hasConceptScore W2068131808C163181125 @default.
• W2068131808 hasConceptScore W2068131808C178498320 @default.
• W2068131808 hasConceptScore W2068131808C181199279 @default.
• W2068131808 hasConceptScore W2068131808C185592680 @default.

• next