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• W2068132526 endingPage "156" @default.
• W2068132526 startingPage "149" @default.
• W2068132526 abstract "•Mst1/Mst2/Hippo are core, conserved components of a tumor suppressor pathway. •Mst/Hippo signaling has both similarities and key differences between mammals and flies. •Homo- and heterodimerization play important roles in Mst regulation. Initially identified as mammalian homologs to yeast Ste20 kinases, the mammalian sterile twenty-like (Mst) 1/2 kinases have been widely investigated subsequent to their rediscovery as key components of the Hippo tumor suppressor pathway in flies. To date, our understanding of Mst substrates and downstream signaling outstrips our knowledge of how these enzymes are controlled by upstream signals. While much remains to be discovered regarding the mechanisms of Mst regulation, it is clear that Mst1 kinase activity is governed at least in part by its state of dimerization, including self-association and also heterodimerization with various other signaling partners. Here we review the basic architecture of Mst signaling and function and discuss recent advances in our understanding of how these important kinases are regulated. Initially identified as mammalian homologs to yeast Ste20 kinases, the mammalian sterile twenty-like (Mst) 1/2 kinases have been widely investigated subsequent to their rediscovery as key components of the Hippo tumor suppressor pathway in flies. To date, our understanding of Mst substrates and downstream signaling outstrips our knowledge of how these enzymes are controlled by upstream signals. While much remains to be discovered regarding the mechanisms of Mst regulation, it is clear that Mst1 kinase activity is governed at least in part by its state of dimerization, including self-association and also heterodimerization with various other signaling partners. Here we review the basic architecture of Mst signaling and function and discuss recent advances in our understanding of how these important kinases are regulated." @default.
• W2068132526 created "2016-06-24" @default.
• W2068132526 creator A5004591046 @default.
• W2068132526 creator A5067925871 @default.
• W2068132526 date "2015-03-01" @default.
• W2068132526 modified "2023-10-17" @default.
• W2068132526 title "Regulation of mammalian Ste20 (Mst) kinases" @default.
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• W2068132526 doi "https://doi.org/10.1016/j.tibs.2015.01.001" @default.
• W2068132526 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4340714" @default.
• W2068132526 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25665457" @default.
• W2068132526 hasPublicationYear "2015" @default.
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