FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068133096> ?p ?o ?g. }

• W2068133096 endingPage "119" @default.
• W2068133096 startingPage "81" @default.
• W2068133096 abstract "Various methods for separating eleven different types of topoisomerase II (TOPO-2) inhibitors, including epipodophyllotoxins, anthracyclines, anthracenediones, anthrapyrazoles, anthracenebishydrazones, indole derivatives, aminoacridines, benzisoquinolinediones, isoflavones, bisdioxopiperazines and thiobarbituric acids, are summarized. Proper sample preparation and storage is critical to the successful analysis of some TOPO-2 inhibitors due to difficulties associated with adsorption, instability and complex biological components. Solid-phase and liquid-liquid extractions are widely used to separate TOPO-2 inhibitors from biological samples, although simple deproteinization followed by direct analysis of the supernatant is preferable to extraction based on its speed and simplicity. High-performance liquid chromatography (HPLC) is the favored method for the bioanalysis of TOPO-2 inhibitors. UV or diode array detection is generally employed for early pharmacokinetic studies, while fluorescence or electrochemical detection is used more frequently for analytes with fluorescent or oxidative-reductive properties. For analyses requiring highly sensitive and/or specific detection, electrospray mass spectrometry (ESI-MS or ESI-MS-MS) provides a suitable alternative. A comprehensive compilation of the HPLC techniques currently used to separate TOPO-2 inhibitors will aid the future development of analytical methods for new TOPO-2 inhibitors." @default.
• W2068133096 created "2016-06-24" @default.
• W2068133096 creator A5042388168 @default.
• W2068133096 creator A5047526614 @default.
• W2068133096 creator A5091381226 @default.
• W2068133096 date "2001-11-01" @default.
• W2068133096 modified "2023-09-24" @default.
• W2068133096 title "High-performance liquid chromatographic methods for the determination of topoisomerase II inhibitors" @default.
• W2068133096 cites W125325141 @default.
• W2068133096 cites W1483085618 @default.
• W2068133096 cites W1656644300 @default.
• W2068133096 cites W1766927792 @default.
• W2068133096 cites W1790602060 @default.
• W2068133096 cites W1900745022 @default.
• W2068133096 cites W1908115926 @default.
• W2068133096 cites W1913023165 @default.
• W2068133096 cites W1963862361 @default.
• W2068133096 cites W1964774257 @default.
• W2068133096 cites W1966456567 @default.
• W2068133096 cites W1967184169 @default.
• W2068133096 cites W1967191193 @default.
• W2068133096 cites W1968134942 @default.
• W2068133096 cites W1968467066 @default.
• W2068133096 cites W1968688093 @default.
• W2068133096 cites W1968860084 @default.
• W2068133096 cites W1969656310 @default.
• W2068133096 cites W1970307507 @default.
• W2068133096 cites W1970328350 @default.
• W2068133096 cites W1970732530 @default.
• W2068133096 cites W1971439708 @default.
• W2068133096 cites W1971717722 @default.
• W2068133096 cites W1971915941 @default.
• W2068133096 cites W1972998454 @default.
• W2068133096 cites W1974355485 @default.
• W2068133096 cites W1975389969 @default.
• W2068133096 cites W1978127085 @default.
• W2068133096 cites W1978737074 @default.
• W2068133096 cites W1979547768 @default.
• W2068133096 cites W1979625274 @default.
• W2068133096 cites W1981958781 @default.
• W2068133096 cites W1982767237 @default.
• W2068133096 cites W1983918782 @default.
• W2068133096 cites W1984116181 @default.
• W2068133096 cites W1985155983 @default.
• W2068133096 cites W1985715288 @default.
• W2068133096 cites W1986798177 @default.
• W2068133096 cites W1987161772 @default.
• W2068133096 cites W1987325811 @default.
• W2068133096 cites W1987516501 @default.
• W2068133096 cites W1987947840 @default.
• W2068133096 cites W1988086962 @default.
• W2068133096 cites W1988167425 @default.
• W2068133096 cites W1991479221 @default.
• W2068133096 cites W1992437129 @default.
• W2068133096 cites W1994826152 @default.
• W2068133096 cites W1994826419 @default.
• W2068133096 cites W1996564028 @default.
• W2068133096 cites W1996787813 @default.
• W2068133096 cites W1996887519 @default.
• W2068133096 cites W1997931135 @default.
• W2068133096 cites W1998224072 @default.
• W2068133096 cites W1998567352 @default.
• W2068133096 cites W1998666914 @default.
• W2068133096 cites W1998901735 @default.
• W2068133096 cites W2000162164 @default.
• W2068133096 cites W2000733496 @default.
• W2068133096 cites W2001421897 @default.
• W2068133096 cites W2002462245 @default.
• W2068133096 cites W2004155787 @default.
• W2068133096 cites W2005384806 @default.
• W2068133096 cites W2006896016 @default.
• W2068133096 cites W2007374010 @default.
• W2068133096 cites W2008579976 @default.
• W2068133096 cites W2011285294 @default.
• W2068133096 cites W2012207829 @default.
• W2068133096 cites W2012353841 @default.
• W2068133096 cites W2012810324 @default.
• W2068133096 cites W2013262665 @default.
• W2068133096 cites W2014501523 @default.
• W2068133096 cites W2016676192 @default.
• W2068133096 cites W2016899173 @default.
• W2068133096 cites W2017514705 @default.
• W2068133096 cites W2017680548 @default.
• W2068133096 cites W2018078300 @default.
• W2068133096 cites W2018862418 @default.
• W2068133096 cites W2019647074 @default.
• W2068133096 cites W2019954099 @default.
• W2068133096 cites W2020693730 @default.
• W2068133096 cites W2021040471 @default.
• W2068133096 cites W2021107411 @default.
• W2068133096 cites W2022452861 @default.
• W2068133096 cites W2023153185 @default.
• W2068133096 cites W2023363112 @default.
• W2068133096 cites W2023597199 @default.
• W2068133096 cites W2024322753 @default.
• W2068133096 cites W2026567610 @default.
• W2068133096 cites W2027744884 @default.
• W2068133096 cites W2028206377 @default.

• next