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• W2068133527 abstract "Autophagy is a catabolic process used to deliver cellular material to the lysosome for degradation. The core Vps34/class III phosphatidylinositol 3-kinase (PI3K) complex, consisting of Atg6, Vps15, and Vps34, is highly conserved throughout evolution, critical for recruiting autophagy-related proteins to the preautophagosomal structure and for other vesicular trafficking processes, including vacuolar protein sorting. Atg6 and Vps34 have been well characterized, but the Vps15 kinase remains poorly characterized with most studies focusing on nutrient deprivation-induced autophagy. Here, we investigate the function of Vps15 in different cellular contexts and find that it is necessary for both stress-induced and developmentally programmed autophagy in various tissues in Drosophila melanogaster. Vps15 is required for autophagy that is induced by multiple forms of stress, including nutrient deprivation, hypoxia, and oxidative stress. Furthermore, autophagy that is triggered by physiological stimuli during development in the fat body, intestine, and salivary gland also require the function of Vps15. In addition, we show that Vps15 is necessary for efficient salivary gland protein secretion. These data illustrate the broad importance of Vps15 in multiple forms of autophagy in different animal cells, and also highlight the pleiotropic function of this kinase in multiple vesicle-trafficking pathways." @default.
• W2068133527 created "2016-06-24" @default.
• W2068133527 creator A5024703115 @default.
• W2068133527 creator A5076958499 @default.
• W2068133527 date "2014-10-24" @default.
• W2068133527 modified "2023-10-09" @default.
• W2068133527 title "Vps15 is required for stress induced and developmentally triggered autophagy and salivary gland protein secretion in Drosophila" @default.
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• W2068133527 doi "https://doi.org/10.1038/cdd.2014.174" @default.
• W2068133527 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4326576" @default.
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• W2068133527 hasPublicationYear "2014" @default.
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