Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068138840> ?p ?o ?g. }
- W2068138840 endingPage "136" @default.
- W2068138840 startingPage "129" @default.
- W2068138840 abstract "Most bone-related diseases are characterized by excessive bone resorption by osteoclasts. Receptor activator of nuclear factor-kappa B (NF-κB) ligand (RANKL) has emerged as a major mediator of bone resorption, commonly associated with cancer and chronic inflammatory diseases. Thus inhibitors of RANKL signaling have a potential in preventing bone loss. In the present study, we investigated the ability of triptolide, a diterpenoid isolated from Thunder of God Vine, to inhibit signaling by receptor activator of NF-κB (RANK) and its ligand (RANKL) and to modulate osteoclastogenesis induced by RANKL and human cancer cells. We found that triptolide suppressed RANKL-induced differentiation of precursor cells to osteoclasts, and also inhibited osteoclast formation induced by human breast tumor cells (MDA-MB-231), multiple myeloma cells (U266) and prostate tumor cells (PC-3). Triptolide inhibited RANKL-induced NF-κB activation in osteoclast precursor cells by inhibiting IκBα kinase activation, IκBα phosphorylation, and IκBα degradation. Our results suggest that triptolide effectively inhibits RANKL-induced NF-κB activation and RANKL- and tumor cell-induced osteoclastogenesis. This warrants further study of triptolide as a potential therapy for osteoporosis and cancer-associated bone loss." @default.
- W2068138840 created "2016-06-24" @default.
- W2068138840 creator A5074060136 @default.
- W2068138840 date "2014-10-01" @default.
- W2068138840 modified "2023-10-16" @default.
- W2068138840 title "Triptolide, a diterpene, inhibits osteoclastogenesis, induced by RANKL signaling and human cancer cells" @default.
- W2068138840 cites W1534645474 @default.
- W2068138840 cites W1899515197 @default.
- W2068138840 cites W1965404141 @default.
- W2068138840 cites W1973686525 @default.
- W2068138840 cites W1976382352 @default.
- W2068138840 cites W1981876883 @default.
- W2068138840 cites W1986643690 @default.
- W2068138840 cites W1990185112 @default.
- W2068138840 cites W1999077925 @default.
- W2068138840 cites W2005360870 @default.
- W2068138840 cites W2007415750 @default.
- W2068138840 cites W2014225480 @default.
- W2068138840 cites W2032901533 @default.
- W2068138840 cites W2041581343 @default.
- W2068138840 cites W2042589950 @default.
- W2068138840 cites W2044038461 @default.
- W2068138840 cites W2048299560 @default.
- W2068138840 cites W2049293744 @default.
- W2068138840 cites W2054351138 @default.
- W2068138840 cites W2057333190 @default.
- W2068138840 cites W2066574904 @default.
- W2068138840 cites W2073927082 @default.
- W2068138840 cites W2076974856 @default.
- W2068138840 cites W2086008590 @default.
- W2068138840 cites W2087324367 @default.
- W2068138840 cites W20888715 @default.
- W2068138840 cites W2089605078 @default.
- W2068138840 cites W2093252878 @default.
- W2068138840 cites W2094374305 @default.
- W2068138840 cites W2097304380 @default.
- W2068138840 cites W2106766464 @default.
- W2068138840 cites W2111077139 @default.
- W2068138840 cites W2115962698 @default.
- W2068138840 cites W2127743278 @default.
- W2068138840 cites W2134457900 @default.
- W2068138840 cites W2152038469 @default.
- W2068138840 cites W2152126661 @default.
- W2068138840 cites W2160005424 @default.
- W2068138840 cites W2161962336 @default.
- W2068138840 cites W2163256279 @default.
- W2068138840 cites W4253714908 @default.
- W2068138840 cites W4296249927 @default.
- W2068138840 cites W6760901 @default.
- W2068138840 doi "https://doi.org/10.1016/j.biochi.2014.07.003" @default.
- W2068138840 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25047443" @default.
- W2068138840 hasPublicationYear "2014" @default.
- W2068138840 type Work @default.
- W2068138840 sameAs 2068138840 @default.
- W2068138840 citedByCount "22" @default.
- W2068138840 countsByYear W20681388402015 @default.
- W2068138840 countsByYear W20681388402016 @default.
- W2068138840 countsByYear W20681388402017 @default.
- W2068138840 countsByYear W20681388402018 @default.
- W2068138840 countsByYear W20681388402019 @default.
- W2068138840 countsByYear W20681388402020 @default.
- W2068138840 countsByYear W20681388402021 @default.
- W2068138840 countsByYear W20681388402022 @default.
- W2068138840 crossrefType "journal-article" @default.
- W2068138840 hasAuthorship W2068138840A5074060136 @default.
- W2068138840 hasConcept C121608353 @default.
- W2068138840 hasConcept C126322002 @default.
- W2068138840 hasConcept C134018914 @default.
- W2068138840 hasConcept C170493617 @default.
- W2068138840 hasConcept C185592680 @default.
- W2068138840 hasConcept C190283241 @default.
- W2068138840 hasConcept C2776033226 @default.
- W2068138840 hasConcept C2777730290 @default.
- W2068138840 hasConcept C2779428903 @default.
- W2068138840 hasConcept C2780426850 @default.
- W2068138840 hasConcept C2781164371 @default.
- W2068138840 hasConcept C502942594 @default.
- W2068138840 hasConcept C55493867 @default.
- W2068138840 hasConcept C62478195 @default.
- W2068138840 hasConcept C673006 @default.
- W2068138840 hasConcept C71924100 @default.
- W2068138840 hasConcept C86803240 @default.
- W2068138840 hasConcept C88045685 @default.
- W2068138840 hasConcept C95444343 @default.
- W2068138840 hasConcept C96232424 @default.
- W2068138840 hasConceptScore W2068138840C121608353 @default.
- W2068138840 hasConceptScore W2068138840C126322002 @default.
- W2068138840 hasConceptScore W2068138840C134018914 @default.
- W2068138840 hasConceptScore W2068138840C170493617 @default.
- W2068138840 hasConceptScore W2068138840C185592680 @default.
- W2068138840 hasConceptScore W2068138840C190283241 @default.
- W2068138840 hasConceptScore W2068138840C2776033226 @default.
- W2068138840 hasConceptScore W2068138840C2777730290 @default.
- W2068138840 hasConceptScore W2068138840C2779428903 @default.
- W2068138840 hasConceptScore W2068138840C2780426850 @default.
- W2068138840 hasConceptScore W2068138840C2781164371 @default.
- W2068138840 hasConceptScore W2068138840C502942594 @default.
- W2068138840 hasConceptScore W2068138840C55493867 @default.