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• W2068143735 abstract "Background: Porphyromonas gingivalis lipid A heterogeneity modulates cytokine expression in human cells. This study investigates the effects of two lipid A isoforms of P. gingivalis , lipopolysaccharide (LPS) 1435/1449 and LPS 1690 , on the secretion of proinflammatory and regulatory cytokines in total blood cultures from patients with and without chronic periodontitis (CP). Methods: A cross‐sectional study was conducted in 38 systemically healthy individuals divided in two groups: 1) the CP group (n = 19), in which patients were diagnosed with CP; and 2) the no periodontitis (NP) group (n = 19), which included control patients without CP. Blood samples were collected from all patients, and whole‐blood cell cultures (WBCCs) were stimulated for 48 hours with P. gingivalis LPS 1435/1449 and LPS 1690 and Escherichia coli LPS. Unstimulated WBCCs served as negative controls. The secretion of interferon‐γ (IFN‐γ), interleukin‐10 (IL‐10), and transforming growth factor‐β (TGF‐β) was detected in WBCC supernatants by enzyme‐linked immunosorbent assays. Results: E. coli LPS significantly increased the expression of all cytokines in WBCCs from both the NP and CP groups when compared to non‐stimulated cells (control treatment). P. gingivalis LPS preparations increased IFN‐γ levels in the CP group but not in the NP group when compared with controls ( P <0.05). P. gingivalis LPS preparations also increased IL‐10 and TGF‐β levels in both CP and NP groups, but P. gingivalis LPS 1690 showed a three‐fold increase on IL‐10 production in the NP group ( P <0.05) when compared to P. gingivalis LPS 1435/144 . Conclusions: These data demonstrate that WBCC cell populations obtained from healthy individuals and patients with CP may differ in the cytokine response to P. gingivalis but not E. coli LPS. This is consistent with the notion that CP alters the systemic WBCC response and that this can be detected by the different P. gingivalis LPS structures." @default.
• W2068143735 created "2016-06-24" @default.
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• W2068143735 date "2014-02-01" @default.
• W2068143735 modified "2023-10-17" @default.
• W2068143735 title "Whole-Blood Cultures From Patients With Chronic Periodontitis Respond Differently to<i>Porphyromonas gingivalis</i>but not<i>Escherichia coli</i>Lipopolysaccharide" @default.
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• W2068143735 doi "https://doi.org/10.1902/jop.2013.120735" @default.
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• W2068143735 hasPublicationYear "2014" @default.
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