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• W2068145263 abstract "A Drosophila gene ( KAZ1 ), mapped to cytological position 61A1‐2 on chromosome 3, has been cloned and found to encode multiple splice variants of Kazal‐type serine protease inhibitor‐like proteins. KAZ1 consists of five exons and four alternatively retained introns to produce six transcripts of type AB, C1, C2, C3, D and E . The AB transcript contains two ORFs, of which the upstream one produces a polypeptide α, which has a mitochondrial sorting signal. Localization to mitochondria was confirmed by expression in COS1 cells. The downstream ORF is shared partially with type C1, C2, C3, D and E transcripts and produces polypeptides β, γ, δ and ε when expressed in Drosophila cells. Type C1, C2 and C3 transcripts differ only in the 5′‐noncoding sequence and thus all produce type γ. Polypeptides γ and ε have a signal sequence at their N‐termini and are secreted into the medium while β and δ lack this sequence and remain in the cytoplasm. Isoforms β and ε share a common C‐terminal sequence distinct from that shared by polypeptides γ and δ. The N‐terminal sequences of isoforms β to ε contain a PEST region which could induce rapid intracellular degradation of isoforms β and δ. Sequence analysis of the Kazal‐type domain suggests a similar folding pattern as observed for rhodniin and SPARC/BM‐40. Northern analysis and in situ hybridization showed that the type C3 transcript is predominant and the expression is highest in midgut at larval stage." @default.
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• W2068145263 date "1999-11-15" @default.
• W2068145263 modified "2023-10-17" @default.
• W2068145263 title "A Drosophila gene encoding multiple splice variants of Kazal-type serine protease inhibitor-like proteins with potential destinations of mitochondria, cytosol and the secretory pathway" @default.
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• W2068145263 doi "https://doi.org/10.1046/j.1432-1327.1999.00873.x" @default.
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