Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068147768> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2068147768 abstract "The experiment-based catalytic residue identificationin the enzyme sequences is most accurate. However,the current experimental methods are often too expensive andlabor intensive to handle the rapidly accumulating proteinsequences and structure data. Thus accurate, high-throughputin silico methods for identifying catalytic residues and enzymefunction prediction are much needed. In this paper, we proposea new, sequence-based enzyme catalytic domain predictionmethod by using clustering and information-theoretic approaches.The first step is to perform the sequence clusteringanalysis of enzyme sequences of the same functional category (those with the same EC number). The clustering analysisconstructs a sequence graph where nodes are enzyme sequencesand edges are defined for a pair of sequences with a certaindegree of sequence similarity and uses graph properties suchas biconnected components and articulation points to generatesequence segments common to the enzyme sequences. Thenamino acid subsequences in the common shared regions arealigned and then an information theoretic approach called aggregatedcolumn related scoring scheme is performed to highlightpotential active sites in enzyme sequences. This method wassuccessful in highlighting known catalytic sites in enzymesof E. coli in terms of the Catalytic Site Atlas database.The proposed method is shown not only to be accurate inpredicting potential active sites in the enzyme sequences butalso computationally efficient since the clustering approachutilizes two graph properties that can be computed in linear tothe number edges in the sequence graph and computation ofmutual information does not require much time to compute.Webelieve that the proposed method can be useful for identifyingactive sites of enzyme sequences from many genome projects." @default.
- W2068147768 created "2016-06-24" @default.
- W2068147768 creator A5024894867 @default.
- W2068147768 creator A5090194343 @default.
- W2068147768 date "2011-07-01" @default.
- W2068147768 modified "2023-09-25" @default.
- W2068147768 title "Sequence-Based Enzyme Catalytic Domain Prediction Using Clustering and Aggregated Mutual Information Content" @default.
- W2068147768 cites W1519266993 @default.
- W2068147768 cites W1967293793 @default.
- W2068147768 cites W2002600840 @default.
- W2068147768 cites W2041877620 @default.
- W2068147768 cites W2043904638 @default.
- W2068147768 cites W2055043387 @default.
- W2068147768 cites W2077737382 @default.
- W2068147768 cites W2104514367 @default.
- W2068147768 cites W2132886170 @default.
- W2068147768 cites W2138366649 @default.
- W2068147768 cites W2140000393 @default.
- W2068147768 cites W2141885858 @default.
- W2068147768 cites W2142237411 @default.
- W2068147768 cites W2154333184 @default.
- W2068147768 cites W2158020463 @default.
- W2068147768 cites W2158266834 @default.
- W2068147768 cites W2158783389 @default.
- W2068147768 cites W2164176644 @default.
- W2068147768 doi "https://doi.org/10.1109/hisb.2011.59" @default.
- W2068147768 hasPublicationYear "2011" @default.
- W2068147768 type Work @default.
- W2068147768 sameAs 2068147768 @default.
- W2068147768 citedByCount "0" @default.
- W2068147768 crossrefType "proceedings-article" @default.
- W2068147768 hasAuthorship W2068147768A5024894867 @default.
- W2068147768 hasAuthorship W2068147768A5090194343 @default.
- W2068147768 hasConcept C104317684 @default.
- W2068147768 hasConcept C11413529 @default.
- W2068147768 hasConcept C124101348 @default.
- W2068147768 hasConcept C132525143 @default.
- W2068147768 hasConcept C154945302 @default.
- W2068147768 hasConcept C167625842 @default.
- W2068147768 hasConcept C2778112365 @default.
- W2068147768 hasConcept C41008148 @default.
- W2068147768 hasConcept C45374587 @default.
- W2068147768 hasConcept C45484198 @default.
- W2068147768 hasConcept C54355233 @default.
- W2068147768 hasConcept C73555534 @default.
- W2068147768 hasConcept C80444323 @default.
- W2068147768 hasConcept C86803240 @default.
- W2068147768 hasConcept C88031987 @default.
- W2068147768 hasConceptScore W2068147768C104317684 @default.
- W2068147768 hasConceptScore W2068147768C11413529 @default.
- W2068147768 hasConceptScore W2068147768C124101348 @default.
- W2068147768 hasConceptScore W2068147768C132525143 @default.
- W2068147768 hasConceptScore W2068147768C154945302 @default.
- W2068147768 hasConceptScore W2068147768C167625842 @default.
- W2068147768 hasConceptScore W2068147768C2778112365 @default.
- W2068147768 hasConceptScore W2068147768C41008148 @default.
- W2068147768 hasConceptScore W2068147768C45374587 @default.
- W2068147768 hasConceptScore W2068147768C45484198 @default.
- W2068147768 hasConceptScore W2068147768C54355233 @default.
- W2068147768 hasConceptScore W2068147768C73555534 @default.
- W2068147768 hasConceptScore W2068147768C80444323 @default.
- W2068147768 hasConceptScore W2068147768C86803240 @default.
- W2068147768 hasConceptScore W2068147768C88031987 @default.
- W2068147768 hasLocation W20681477681 @default.
- W2068147768 hasOpenAccess W2068147768 @default.
- W2068147768 hasPrimaryLocation W20681477681 @default.
- W2068147768 hasRelatedWork W130931446 @default.
- W2068147768 hasRelatedWork W1490120815 @default.
- W2068147768 hasRelatedWork W1534697636 @default.
- W2068147768 hasRelatedWork W1910258912 @default.
- W2068147768 hasRelatedWork W2071382179 @default.
- W2068147768 hasRelatedWork W2089453789 @default.
- W2068147768 hasRelatedWork W2092160131 @default.
- W2068147768 hasRelatedWork W2108037661 @default.
- W2068147768 hasRelatedWork W2126080985 @default.
- W2068147768 hasRelatedWork W2142637445 @default.
- W2068147768 hasRelatedWork W2147758638 @default.
- W2068147768 hasRelatedWork W2150415479 @default.
- W2068147768 hasRelatedWork W2155358039 @default.
- W2068147768 hasRelatedWork W2165510880 @default.
- W2068147768 hasRelatedWork W2166830041 @default.
- W2068147768 hasRelatedWork W2167895467 @default.
- W2068147768 hasRelatedWork W2183746069 @default.
- W2068147768 hasRelatedWork W3098344866 @default.
- W2068147768 hasRelatedWork W76317090 @default.
- W2068147768 hasRelatedWork W2142195237 @default.
- W2068147768 isParatext "false" @default.
- W2068147768 isRetracted "false" @default.
- W2068147768 magId "2068147768" @default.
- W2068147768 workType "article" @default.