FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068149369> ?p ?o ?g. }

• W2068149369 endingPage "278" @default.
• W2068149369 startingPage "265" @default.
• W2068149369 abstract "The vitamin A metabolite all-trans retinoic acid (RA) is an important determinant of intestinal immunity. RA primes dendritic cells (DCs) to express CD103 and produce RA themselves, which induces the gut-homing receptors α4β7 and CCR9 on T cells and amplifies transforming growth factor (TGF)-β-mediated development of Foxp3+ regulatory T (Treg) cells. Here we investigated the effect of RA on human DCs and subsequent development of T cells. We report a novel role of RA in immune regulation by showing that RA-conditioned human DCs did not substantially enhance Foxp3 but induced α4β7+ CCR9+ T cells expressing high levels of interleukin (IL)-10, which were functional suppressive Treg cells. IL-10 production was dependent on DC-derived RA and was maintained when DCs were stimulated with toll-like receptor ligands. Furthermore, the presence of TGF-β during RA-DC-driven T-cell priming favored the induction of Foxp3+ Treg cells over IL-10+ Treg cells. Experiments with naive CD4+ T cells stimulated by anti-CD3 and anti-CD28 antibodies in the absence of DCs emphasized that RA induces IL-10 in face of inflammatory mediators. The data thus show for the first time that RA induces IL-10-producing Treg cells and postulates a novel mechanism for IL-10 in maintaining tolerance to the intestinal microbiome." @default.
• W2068149369 created "2016-06-24" @default.
• W2068149369 creator A5003825284 @default.
• W2068149369 creator A5018399610 @default.
• W2068149369 creator A5019354623 @default.
• W2068149369 creator A5028443244 @default.
• W2068149369 creator A5067644591 @default.
• W2068149369 date "2015-03-01" @default.
• W2068149369 modified "2023-10-13" @default.
• W2068149369 title "Retinoic acid primes human dendritic cells to induce gut-homing, IL-10-producing regulatory T cells" @default.
• W2068149369 cites W1549459360 @default.
• W2068149369 cites W1573222062 @default.
• W2068149369 cites W173017759 @default.
• W2068149369 cites W1772839736 @default.
• W2068149369 cites W1903161793 @default.
• W2068149369 cites W1975672348 @default.
• W2068149369 cites W1996087599 @default.
• W2068149369 cites W2001216658 @default.
• W2068149369 cites W2002368408 @default.
• W2068149369 cites W2003481369 @default.
• W2068149369 cites W2007015208 @default.
• W2068149369 cites W2022193427 @default.
• W2068149369 cites W2031222013 @default.
• W2068149369 cites W2031551895 @default.
• W2068149369 cites W2036500213 @default.
• W2068149369 cites W2037259928 @default.
• W2068149369 cites W2039992202 @default.
• W2068149369 cites W2043043717 @default.
• W2068149369 cites W2044069347 @default.
• W2068149369 cites W2062363040 @default.
• W2068149369 cites W2069305891 @default.
• W2068149369 cites W2070502352 @default.
• W2068149369 cites W2070795169 @default.
• W2068149369 cites W2072447036 @default.
• W2068149369 cites W2079517510 @default.
• W2068149369 cites W2084990572 @default.
• W2068149369 cites W2092975931 @default.
• W2068149369 cites W2107513762 @default.
• W2068149369 cites W2107631420 @default.
• W2068149369 cites W2110957620 @default.
• W2068149369 cites W2114026848 @default.
• W2068149369 cites W2114254500 @default.
• W2068149369 cites W2115138114 @default.
• W2068149369 cites W2116432220 @default.
• W2068149369 cites W2116552560 @default.
• W2068149369 cites W2131977720 @default.
• W2068149369 cites W2136097155 @default.
• W2068149369 cites W2144836936 @default.
• W2068149369 cites W2145488426 @default.
• W2068149369 cites W2149755871 @default.
• W2068149369 cites W2151550531 @default.
• W2068149369 cites W2154057864 @default.
• W2068149369 cites W2155463278 @default.
• W2068149369 cites W2160655212 @default.
• W2068149369 cites W2163590547 @default.
• W2068149369 cites W2165339228 @default.
• W2068149369 cites W2165528446 @default.
• W2068149369 cites W2169235809 @default.
• W2068149369 cites W2170292069 @default.
• W2068149369 cites W2170617867 @default.
• W2068149369 cites W2171898230 @default.
• W2068149369 cites W2171904517 @default.
• W2068149369 cites W4313333807 @default.
• W2068149369 doi "https://doi.org/10.1038/mi.2014.64" @default.
• W2068149369 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25027601" @default.
• W2068149369 hasPublicationYear "2015" @default.
• W2068149369 type Work @default.
• W2068149369 sameAs 2068149369 @default.
• W2068149369 citedByCount "182" @default.
• W2068149369 countsByYear W20681493692015 @default.
• W2068149369 countsByYear W20681493692016 @default.
• W2068149369 countsByYear W20681493692017 @default.
• W2068149369 countsByYear W20681493692018 @default.
• W2068149369 countsByYear W20681493692019 @default.
• W2068149369 countsByYear W20681493692020 @default.
• W2068149369 countsByYear W20681493692021 @default.
• W2068149369 countsByYear W20681493692022 @default.
• W2068149369 countsByYear W20681493692023 @default.
• W2068149369 crossrefType "journal-article" @default.
• W2068149369 hasAuthorship W2068149369A5003825284 @default.
• W2068149369 hasAuthorship W2068149369A5018399610 @default.
• W2068149369 hasAuthorship W2068149369A5019354623 @default.
• W2068149369 hasAuthorship W2068149369A5028443244 @default.
• W2068149369 hasAuthorship W2068149369A5067644591 @default.
• W2068149369 hasBestOaLocation W20681493691 @default.
• W2068149369 hasConcept C100701293 @default.
• W2068149369 hasConcept C203014093 @default.
• W2068149369 hasConcept C2776090121 @default.
• W2068149369 hasConcept C2779727006 @default.
• W2068149369 hasConcept C2781121885 @default.
• W2068149369 hasConcept C54355233 @default.
• W2068149369 hasConcept C59822182 @default.
• W2068149369 hasConcept C79484868 @default.
• W2068149369 hasConcept C81444415 @default.
• W2068149369 hasConcept C81885089 @default.
• W2068149369 hasConcept C86803240 @default.
• W2068149369 hasConcept C8891405 @default.
• W2068149369 hasConcept C95444343 @default.

• next