FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068149733> ?p ?o ?g. }

• W2068149733 endingPage "139" @default.
• W2068149733 startingPage "132" @default.
• W2068149733 abstract "Most of methylxanthine derivatives including caffeine have been known to radiosensitize cancer cells, but the obstacles such as toxicity, request of high dose and poor solubility hinder their preclinical evaluations and clinical applications. In this study, we evaluated the efficacy of 1-methylxanthine (1-MTX), a caffeine metabolite as a radiosensitizer and the in vivo effectiveness of the temperature-sensitive liposomal 1-methylxanthine (tsl-MTX) in combination with ionizing radiation and regional hyperthermia. In human colorectal and lung cancer cells, treatment of 1-MTX sensitized cells to ionizing radiation. To evaluate the in vivo capability of 1-MTX to radiosensitize tumors, we developed temperature-sensitive liposomal 1-MTX using DPPC:DMPC:DSPC (4:1:1 molar ratio) with intention of overcoming lethal toxicity of 1-MTX and controlling drug-release. The particle size of the liposomes was approximately 200 nm in diameter. The release of 1-MTX from the liposomes was responding to increase of temperature. In xenograft tumor-bearing mice, the tsl-MTX administered using the i.p. route showed delay of tumor growth. Importantly, tsl-MTX in combination with radiation and regional hyperthermia exhibited marked delay of tumor growth, suggesting that 1-MTX effectively enhanced radiation-induced suppression of tumor growth. In conclusion, tsl-MTX has highly efficacious anticancer competence in vivo, enhancing radiotherapeutic effectiveness, and feasibility for further clinical applications." @default.
• W2068149733 created "2016-06-24" @default.
• W2068149733 creator A5000363855 @default.
• W2068149733 creator A5003798955 @default.
• W2068149733 creator A5013175108 @default.
• W2068149733 creator A5018860908 @default.
• W2068149733 creator A5023313081 @default.
• W2068149733 creator A5025995653 @default.
• W2068149733 creator A5026121378 @default.
• W2068149733 creator A5046815714 @default.
• W2068149733 creator A5047972496 @default.
• W2068149733 creator A5084014218 @default.
• W2068149733 creator A5084662421 @default.
• W2068149733 creator A5086618143 @default.
• W2068149733 date "2009-05-01" @default.
• W2068149733 modified "2023-09-23" @default.
• W2068149733 title "Enhancement of radiotherapeutic effectiveness by temperature-sensitive liposomal 1-methylxanthine" @default.
• W2068149733 cites W1875453987 @default.
• W2068149733 cites W1896635905 @default.
• W2068149733 cites W1977541278 @default.
• W2068149733 cites W1988876917 @default.
• W2068149733 cites W1996158048 @default.
• W2068149733 cites W1996834203 @default.
• W2068149733 cites W2002696717 @default.
• W2068149733 cites W2012486985 @default.
• W2068149733 cites W2012992842 @default.
• W2068149733 cites W2029134404 @default.
• W2068149733 cites W2030768015 @default.
• W2068149733 cites W2030855909 @default.
• W2068149733 cites W2034319316 @default.
• W2068149733 cites W2040150720 @default.
• W2068149733 cites W2044569715 @default.
• W2068149733 cites W2048772171 @default.
• W2068149733 cites W2057850047 @default.
• W2068149733 cites W2057949133 @default.
• W2068149733 cites W2058583494 @default.
• W2068149733 cites W2064458964 @default.
• W2068149733 cites W2070439117 @default.
• W2068149733 cites W2078730133 @default.
• W2068149733 cites W2097173890 @default.
• W2068149733 cites W2101087508 @default.
• W2068149733 cites W2102752109 @default.
• W2068149733 cites W2105768236 @default.
• W2068149733 cites W2133853290 @default.
• W2068149733 cites W2153685985 @default.
• W2068149733 cites W2178273106 @default.
• W2068149733 doi "https://doi.org/10.1016/j.ijpharm.2008.12.040" @default.
• W2068149733 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19167476" @default.
• W2068149733 hasPublicationYear "2009" @default.
• W2068149733 type Work @default.
• W2068149733 sameAs 2068149733 @default.
• W2068149733 citedByCount "14" @default.
• W2068149733 countsByYear W20681497332012 @default.
• W2068149733 countsByYear W20681497332013 @default.
• W2068149733 countsByYear W20681497332014 @default.
• W2068149733 countsByYear W20681497332015 @default.
• W2068149733 countsByYear W20681497332016 @default.
• W2068149733 countsByYear W20681497332018 @default.
• W2068149733 countsByYear W20681497332021 @default.
• W2068149733 countsByYear W20681497332023 @default.
• W2068149733 crossrefType "journal-article" @default.
• W2068149733 hasAuthorship W2068149733A5000363855 @default.
• W2068149733 hasAuthorship W2068149733A5003798955 @default.
• W2068149733 hasAuthorship W2068149733A5013175108 @default.
• W2068149733 hasAuthorship W2068149733A5018860908 @default.
• W2068149733 hasAuthorship W2068149733A5023313081 @default.
• W2068149733 hasAuthorship W2068149733A5025995653 @default.
• W2068149733 hasAuthorship W2068149733A5026121378 @default.
• W2068149733 hasAuthorship W2068149733A5046815714 @default.
• W2068149733 hasAuthorship W2068149733A5047972496 @default.
• W2068149733 hasAuthorship W2068149733A5084014218 @default.
• W2068149733 hasAuthorship W2068149733A5084662421 @default.
• W2068149733 hasAuthorship W2068149733A5086618143 @default.
• W2068149733 hasConcept C126322002 @default.
• W2068149733 hasConcept C150903083 @default.
• W2068149733 hasConcept C185154212 @default.
• W2068149733 hasConcept C185592680 @default.
• W2068149733 hasConcept C207001950 @default.
• W2068149733 hasConcept C2776428644 @default.
• W2068149733 hasConcept C2779949491 @default.
• W2068149733 hasConcept C29730261 @default.
• W2068149733 hasConcept C509974204 @default.
• W2068149733 hasConcept C55493867 @default.
• W2068149733 hasConcept C71924100 @default.
• W2068149733 hasConcept C86803240 @default.
• W2068149733 hasConcept C98274493 @default.
• W2068149733 hasConceptScore W2068149733C126322002 @default.
• W2068149733 hasConceptScore W2068149733C150903083 @default.
• W2068149733 hasConceptScore W2068149733C185154212 @default.
• W2068149733 hasConceptScore W2068149733C185592680 @default.
• W2068149733 hasConceptScore W2068149733C207001950 @default.
• W2068149733 hasConceptScore W2068149733C2776428644 @default.
• W2068149733 hasConceptScore W2068149733C2779949491 @default.
• W2068149733 hasConceptScore W2068149733C29730261 @default.
• W2068149733 hasConceptScore W2068149733C509974204 @default.
• W2068149733 hasConceptScore W2068149733C55493867 @default.
• W2068149733 hasConceptScore W2068149733C71924100 @default.
• W2068149733 hasConceptScore W2068149733C86803240 @default.

• next