FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068155003> ?p ?o ?g. }

• W2068155003 endingPage "329" @default.
• W2068155003 startingPage "311" @default.
• W2068155003 abstract "Obesity and its associated metabolic disorders are growing health concerns in the US and worldwide. In the US alone, more than two-thirds of the adult population is classified as either overweight or obese [1], highlighting the need to develop new, effective treatments for these conditions. Whereas the hormone oxytocin is well known for its peripheral effects on uterine contraction during parturition and milk ejection during lactation, release of oxytocin from somatodendrites and axonal terminals within the central nervous system (CNS) is implicated in both the formation of prosocial behaviors and in the control of energy balance. Recent findings demonstrate that chronic administration of oxytocin reduces food intake and body weight in diet-induced obese (DIO) and genetically obese rodents with impaired or defective leptin signaling. Importantly, chronic systemic administration of oxytocin out to 6 weeks recapitulates the effects of central administration on body weight loss in DIO rodents at doses that do not result in the development of tolerance. Furthermore, these effects are coupled with induction of Fos (a marker of neuronal activation) in hindbrain areas (e.g. dorsal vagal complex (DVC)) linked to the control of meal size and forebrain areas (e.g. hypothalamus, amygdala) linked to the regulation of food intake and body weight. This review assesses the potential central and peripheral targets by which oxytocin may inhibit body weight gain, its regulation by anorexigenic and orexigenic signals, and its potential use as a therapy that can circumvent leptin resistance and reverse the behavioral and metabolic abnormalities associated with DIO and genetically obese models." @default.
• W2068155003 created "2016-06-24" @default.
• W2068155003 creator A5072537678 @default.
• W2068155003 creator A5075250635 @default.
• W2068155003 date "2013-09-25" @default.
• W2068155003 modified "2023-10-17" @default.
• W2068155003 title "Role of oxytocin signaling in the regulation of body weight" @default.
• W2068155003 cites W1490643348 @default.
• W2068155003 cites W1505876840 @default.
• W2068155003 cites W1532178599 @default.
• W2068155003 cites W1557170584 @default.
• W2068155003 cites W1561443084 @default.
• W2068155003 cites W1593834182 @default.
• W2068155003 cites W1594116056 @default.
• W2068155003 cites W1595123071 @default.
• W2068155003 cites W1595671608 @default.
• W2068155003 cites W1714474526 @default.
• W2068155003 cites W1719679764 @default.
• W2068155003 cites W1923800470 @default.
• W2068155003 cites W1938774134 @default.
• W2068155003 cites W1964562779 @default.
• W2068155003 cites W1965959062 @default.
• W2068155003 cites W1966059930 @default.
• W2068155003 cites W1966985989 @default.
• W2068155003 cites W1967734976 @default.
• W2068155003 cites W1970498004 @default.
• W2068155003 cites W1972079819 @default.
• W2068155003 cites W1972240031 @default.
• W2068155003 cites W1973821096 @default.
• W2068155003 cites W1974838371 @default.
• W2068155003 cites W1975169309 @default.
• W2068155003 cites W1977361173 @default.
• W2068155003 cites W1977571624 @default.
• W2068155003 cites W1983698556 @default.
• W2068155003 cites W1984212078 @default.
• W2068155003 cites W1984838611 @default.
• W2068155003 cites W1985205570 @default.
• W2068155003 cites W1985210505 @default.
• W2068155003 cites W1985605151 @default.
• W2068155003 cites W1985754352 @default.
• W2068155003 cites W1985898366 @default.
• W2068155003 cites W1986423267 @default.
• W2068155003 cites W1986838464 @default.
• W2068155003 cites W1988112870 @default.
• W2068155003 cites W1989616977 @default.
• W2068155003 cites W1990598085 @default.
• W2068155003 cites W1991216772 @default.
• W2068155003 cites W1991434889 @default.
• W2068155003 cites W1991834855 @default.
• W2068155003 cites W1995774252 @default.
• W2068155003 cites W1997126400 @default.
• W2068155003 cites W1997242658 @default.
• W2068155003 cites W1997331889 @default.
• W2068155003 cites W1997981295 @default.
• W2068155003 cites W1998893802 @default.
• W2068155003 cites W2000030399 @default.
• W2068155003 cites W2000544033 @default.
• W2068155003 cites W2001160654 @default.
• W2068155003 cites W2001486453 @default.
• W2068155003 cites W2003590296 @default.
• W2068155003 cites W2005665656 @default.
• W2068155003 cites W2006244956 @default.
• W2068155003 cites W2006629663 @default.
• W2068155003 cites W2006841717 @default.
• W2068155003 cites W2007356045 @default.
• W2068155003 cites W2008016881 @default.
• W2068155003 cites W2008667373 @default.
• W2068155003 cites W2009762469 @default.
• W2068155003 cites W2009849294 @default.
• W2068155003 cites W2009935964 @default.
• W2068155003 cites W2011628863 @default.
• W2068155003 cites W2011847859 @default.
• W2068155003 cites W2012169215 @default.
• W2068155003 cites W2012453827 @default.
• W2068155003 cites W2013694191 @default.
• W2068155003 cites W2015103793 @default.
• W2068155003 cites W2015172493 @default.
• W2068155003 cites W2016821300 @default.
• W2068155003 cites W2016886211 @default.
• W2068155003 cites W2018122894 @default.
• W2068155003 cites W2018172047 @default.
• W2068155003 cites W2018594569 @default.
• W2068155003 cites W2018872272 @default.
• W2068155003 cites W2020441421 @default.
• W2068155003 cites W2021650763 @default.
• W2068155003 cites W2021699660 @default.
• W2068155003 cites W2022151858 @default.
• W2068155003 cites W2023780399 @default.
• W2068155003 cites W2026117260 @default.
• W2068155003 cites W2026404294 @default.
• W2068155003 cites W2026730925 @default.
• W2068155003 cites W2028244020 @default.
• W2068155003 cites W2028325435 @default.
• W2068155003 cites W2029329795 @default.
• W2068155003 cites W2029555615 @default.
• W2068155003 cites W2032705776 @default.
• W2068155003 cites W2035269878 @default.
• W2068155003 cites W2035541519 @default.

• next