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- W2068155779 abstract "We used a whole cell patch clamp technique to study the effects of ropivacaine on rat dorsal horn neurons. Under voltage clamp, ropivacaine (10–400 μM) produced a dose-dependent inhibition of sodium current. From a holding potential (Vh) of −80 mV, sodium currents evoked by test pulses to 0 mV were inhibited by ropivacaine with a mean drug concentration required to produce 50% current inhibition (IC50) value of 117.3 μM, which was more than the value of the bupivacaine (IC50 53.7 μM). The inhibition effect of ropivacaine was also voltage-dependent. Current evoked from a Vh of −60 mV was inhibited by ropivacaine with a mean IC50 value of 74.3 μM, which was less than that obtained at the Vh of −80 mV. The inhibition effect of ropivacaine on sodium current was use dependent. Repeated activation by a train of depolarizing pulses (5 Hz, 20 ms) increased the inhibitory effects of ropivacaine. The ratio amplitudes of the 20th to the first pulse were 91.2% and 71.1%, respectively, in the absence and presence of ropivacaine (50 μM). Ropivacaine also produced a significant hyperpolarizing shift of 11 mV in the steady-state inactivation curve of sodium current. The inhibition of ropivacaine on the sodium channel may contribute to the mechanism of action of local anesthetics during epidural and spinal anesthesia. Implications By using the whole-cell patch technique, ropivacaine is a voltage- and use-dependent inhibitor of the sodium current in dorsal horn neurons; it preferentially acts on steady-state inactivation by the sodium channel. The inhibition of ropivacaine on the sodium channel may contribute to the mechanism of action of local anesthetics during epidural and spinal anesthesia." @default.
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- W2068155779 date "2000-05-01" @default.
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- W2068155779 title "The Effects of Ropivacaine on Sodium Currents in Dorsal Horn Neurons of Neonatal Rats" @default.
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- W2068155779 doi "https://doi.org/10.1097/00000539-200005000-00007" @default.
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