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- W2068156404 abstract "Actions of 5alpha-pregnan-3alpha-ol-20-one (3alpha,5alpha-THP), in the midbrain ventral tegmental area (VTA) modulate sexual receptivity of female rats. Actions of 3alpha,5alpha-THP at GABAergic substrates in the VTA are known to modulate consummatory aspects of sexual behavior among rodents, such as lordosis. However, the extent to which GABA(A) receptors in the VTA are important for appetitive (exploratory, anti-anxiety, social) aspects of sexual receptivity is not well-understood. Proestrous rats were bilaterally-infused with saline or bicuculline (100 ng), a GABA(A) receptor antagonist, to the VTA or missed control sites. Rats were assessed for exploratory/anti-anxiety (open field/elevated plus maze), social (social interaction), and sexual (paced-mating) behavior. Compared to saline or missed site controls, intra-VTA bicuculline significantly reduced the number of central entries in an open field, time spent on the open arms of an elevated plus maze, frequency and intensity of lordosis, anti-aggression towards a male, pacing of sexual contacts, and 3alpha,5alpha-THP concentrations in midbrain and hippocampus. Bicuculline-infused rats also displayed less affiliation with a novel conspecific, fewer sexual solicitations, and had lower 3alpha,5alpha-THP concentrations in diencephalon and cortex, albeit these were not significant differences. Thus, actions at GABA(A) receptors in the midbrain VTA are essential for appetitive and consummatory aspects of sexual receptivity among rats." @default.
- W2068156404 created "2016-06-24" @default.
- W2068156404 creator A5009051197 @default.
- W2068156404 creator A5014443035 @default.
- W2068156404 date "2009-10-01" @default.
- W2068156404 modified "2023-10-13" @default.
- W2068156404 title "Infusions of bicuculline to the ventral tegmental area attenuates sexual, exploratory, and anti-anxiety behavior of proestrous rats" @default.
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- W2068156404 doi "https://doi.org/10.1016/j.pbb.2009.06.012" @default.
- W2068156404 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2744290" @default.
- W2068156404 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19576238" @default.
- W2068156404 hasPublicationYear "2009" @default.
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