Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068156633> ?p ?o ?g. }
- W2068156633 endingPage "531" @default.
- W2068156633 startingPage "517" @default.
- W2068156633 abstract "Lissencephaly is a devastating neurological disorder caused by defective neuronal migration. The LIS1 (or PAFAH1B1) gene was identified as the gene mutated in lissencephaly patients, and was found to regulate cytoplasmic dynein function and localization. In particular, LIS1 is essential for anterograde transport of cytoplasmic dynein as a part of the cytoplasmic dynein-LIS1-microtubule complex in a kinesin-1-dependent manner. However, the underlying mechanism by which a cytoplasmic dynein-LIS1-microtubule complex binds kinesin-1 is unknown. Here, we report that mNUDC (mammalian NUDC) interacts with kinesin-1 and is required for the anterograde transport of a cytoplasmic dynein complex by kinesin-1. mNUDC is also required for anterograde transport of a dynactin-containing complex. Inhibition of mNUDC severely suppressed anterograde transport of distinct cytoplasmic dynein and dynactin complexes, whereas motility of kinesin-1 remained intact. Reconstruction experiments clearly demonstrated that mNUDC mediates the interaction of the dynein or dynactin complex with kinesin-1 and supports their transport by kinesin-1. Our findings have uncovered an essential role of mNUDC for anterograde transport of dynein and dynactin by kinesin-1." @default.
- W2068156633 created "2016-06-24" @default.
- W2068156633 creator A5000101865 @default.
- W2068156633 creator A5000405790 @default.
- W2068156633 creator A5020638596 @default.
- W2068156633 creator A5029250115 @default.
- W2068156633 creator A5040530002 @default.
- W2068156633 creator A5042911899 @default.
- W2068156633 creator A5061814214 @default.
- W2068156633 creator A5068549728 @default.
- W2068156633 creator A5069496790 @default.
- W2068156633 creator A5069712812 @default.
- W2068156633 creator A5076258679 @default.
- W2068156633 creator A5083605341 @default.
- W2068156633 creator A5090108427 @default.
- W2068156633 date "2009-12-17" @default.
- W2068156633 modified "2023-10-10" @default.
- W2068156633 title "mNUDC is required for plus-end-directed transport of cytoplasmic dynein and dynactins by kinesin-1" @default.
- W2068156633 cites W102506034 @default.
- W2068156633 cites W1481912803 @default.
- W2068156633 cites W1495907309 @default.
- W2068156633 cites W1528749730 @default.
- W2068156633 cites W1561680043 @default.
- W2068156633 cites W1592694972 @default.
- W2068156633 cites W1956978115 @default.
- W2068156633 cites W1976175605 @default.
- W2068156633 cites W1989571574 @default.
- W2068156633 cites W1992502425 @default.
- W2068156633 cites W199497138 @default.
- W2068156633 cites W2000265293 @default.
- W2068156633 cites W2005633093 @default.
- W2068156633 cites W2007253244 @default.
- W2068156633 cites W2015229379 @default.
- W2068156633 cites W2017929785 @default.
- W2068156633 cites W2036623899 @default.
- W2068156633 cites W2037835429 @default.
- W2068156633 cites W2039252375 @default.
- W2068156633 cites W2042992389 @default.
- W2068156633 cites W2058219169 @default.
- W2068156633 cites W2075366096 @default.
- W2068156633 cites W2077347535 @default.
- W2068156633 cites W2080893376 @default.
- W2068156633 cites W2082631326 @default.
- W2068156633 cites W2084625595 @default.
- W2068156633 cites W2090453526 @default.
- W2068156633 cites W2095790288 @default.
- W2068156633 cites W2096558699 @default.
- W2068156633 cites W2099198611 @default.
- W2068156633 cites W2105361671 @default.
- W2068156633 cites W2105851524 @default.
- W2068156633 cites W2116811981 @default.
- W2068156633 cites W2120696154 @default.
- W2068156633 cites W2125819380 @default.
- W2068156633 cites W2128804867 @default.
- W2068156633 cites W2131544701 @default.
- W2068156633 cites W2134505334 @default.
- W2068156633 cites W2153292012 @default.
- W2068156633 cites W2159965729 @default.
- W2068156633 cites W2162117855 @default.
- W2068156633 cites W2166629347 @default.
- W2068156633 cites W2210086182 @default.
- W2068156633 cites W2415110637 @default.
- W2068156633 cites W4246573955 @default.
- W2068156633 doi "https://doi.org/10.1038/emboj.2009.378" @default.
- W2068156633 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2830693" @default.
- W2068156633 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20019668" @default.
- W2068156633 hasPublicationYear "2009" @default.
- W2068156633 type Work @default.
- W2068156633 sameAs 2068156633 @default.
- W2068156633 citedByCount "54" @default.
- W2068156633 countsByYear W20681566332012 @default.
- W2068156633 countsByYear W20681566332013 @default.
- W2068156633 countsByYear W20681566332014 @default.
- W2068156633 countsByYear W20681566332015 @default.
- W2068156633 countsByYear W20681566332016 @default.
- W2068156633 countsByYear W20681566332017 @default.
- W2068156633 countsByYear W20681566332018 @default.
- W2068156633 countsByYear W20681566332020 @default.
- W2068156633 countsByYear W20681566332021 @default.
- W2068156633 countsByYear W20681566332022 @default.
- W2068156633 crossrefType "journal-article" @default.
- W2068156633 hasAuthorship W2068156633A5000101865 @default.
- W2068156633 hasAuthorship W2068156633A5000405790 @default.
- W2068156633 hasAuthorship W2068156633A5020638596 @default.
- W2068156633 hasAuthorship W2068156633A5029250115 @default.
- W2068156633 hasAuthorship W2068156633A5040530002 @default.
- W2068156633 hasAuthorship W2068156633A5042911899 @default.
- W2068156633 hasAuthorship W2068156633A5061814214 @default.
- W2068156633 hasAuthorship W2068156633A5068549728 @default.
- W2068156633 hasAuthorship W2068156633A5069496790 @default.
- W2068156633 hasAuthorship W2068156633A5069712812 @default.
- W2068156633 hasAuthorship W2068156633A5076258679 @default.
- W2068156633 hasAuthorship W2068156633A5083605341 @default.
- W2068156633 hasAuthorship W2068156633A5090108427 @default.
- W2068156633 hasBestOaLocation W20681566332 @default.
- W2068156633 hasConcept C106987784 @default.
- W2068156633 hasConcept C134729014 @default.
- W2068156633 hasConcept C190062978 @default.