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- W2068156672 abstract "We show that a three-stage stochastic model of carcinogenesis with a discretized transition probability from the intermediate (hyperplastic) stage to the final (clinically malignant) stage leads to an equation which can be fitted to a wide variety of age-incidence curves for female breast cancer. This includes the inflected (so-called biphasic) incidences observed in many Western countries, as well as the peaked profiles observed in the Orient. Unlike previous mathematical theories which attribute biphasic incidence to a superposition of profiles for two etiologically distinct diseases, the theory presented here hypothesizes its biologic basis as change in ovarian functions accompanying menopause. This leads to an equation which fits the data equally well, though with fewer adjustable parameters. The extent to which the theory simulates the effect of various risk factors, including age at menarche, menopause and first birth, is briefly discussed." @default.
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- W2068156672 date "1977-01-01" @default.
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- W2068156672 title "The age incidence of female breast cancer— simple models and analysis of epidemiological patterns" @default.
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- W2068156672 doi "https://doi.org/10.1016/0025-5564(77)90095-5" @default.
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