FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068163722> ?p ?o ?g. }

• W2068163722 endingPage "47" @default.
• W2068163722 startingPage "41" @default.
• W2068163722 abstract "The generation of GT-Ko mice has provided unique opportunities to study allograft and xenograft rejection in the context of anti-alpha1,3-Gal antibody (anti-Gal Ab) responses. In this study we used the allotransplantation model of C3H hearts into galactosyltransferase-deficient (GT-Ko) mice and the xenotransplantation model of baby Lewis rat hearts into GT-Ko mice to investigate the ability of CTLA-41g in combination with anti-CD40L mAb to control graft rejection and anti-Gal Ab production. Murine CTLA-41g or anti-CD40L monotherapy prolonged allograft survival, and the combination of these reagents was most immunosuppressive. However short-term treatment with murine cytotoxic T lymphocyte associated antigen-4 (muCTLA-41g) and/or CD40 ligand (CD154) monoclonal antibodies (anti-CD40L mAbs) was unable to induce indefinite allograft survival. CTLA-4-immunoglobulin fusion protein (CTLA-41g) or anti-CD40L monotherapy only marginally prolonged xenograft survival; the combination of human CTLA-41g and anti-CD40L significantly prolonged xenograft survival (74days), while the combination of murine CTLA-41g and anti-CD40L resulted in graft survival of >120days. CTLA-41g or anti-CD40L monotherapy or the combination of these agents inhibited the production of alloAbs, including anti-Gal Abs. CTLA-41g or anti-CD40L monotherapy partially controlled xenoAb and anti-Gal Ab production, while the combination was more effective. These observations corroborate our previous observations that humoral, including anti-Gal Ab, responses and rejection following allograft or concordant xenograft transplantation in GT-Ko mice are T-cell dependent and can be controlled by costimulation blockade." @default.
• W2068163722 created "2016-06-24" @default.
• W2068163722 creator A5004584175 @default.
• W2068163722 creator A5008750595 @default.
• W2068163722 creator A5027563261 @default.
• W2068163722 creator A5052690820 @default.
• W2068163722 creator A5090706571 @default.
• W2068163722 creator A5091360661 @default.
• W2068163722 date "2002-01-01" @default.
• W2068163722 modified "2023-09-23" @default.
• W2068163722 title "CTLA-4Ig in Combination with Anti-CD40L Prolongs Xenograft Survival and Inhibits Anti-Gal Ab Production in GT-Ko Mice" @default.
• W2068163722 cites W1522565350 @default.
• W2068163722 cites W1581554632 @default.
• W2068163722 cites W1973519414 @default.
• W2068163722 cites W1989484846 @default.
• W2068163722 cites W2023492750 @default.
• W2068163722 cites W2027284410 @default.
• W2068163722 cites W2035455050 @default.
• W2068163722 cites W2043122674 @default.
• W2068163722 cites W2048769067 @default.
• W2068163722 cites W2052938585 @default.
• W2068163722 cites W2054083392 @default.
• W2068163722 cites W2054108073 @default.
• W2068163722 cites W2055600855 @default.
• W2068163722 cites W2067384559 @default.
• W2068163722 cites W2068269731 @default.
• W2068163722 cites W2070560917 @default.
• W2068163722 cites W2077389439 @default.
• W2068163722 cites W2088370636 @default.
• W2068163722 cites W2090992688 @default.
• W2068163722 cites W2096370504 @default.
• W2068163722 cites W2099991426 @default.
• W2068163722 cites W2110643811 @default.
• W2068163722 cites W2110762398 @default.
• W2068163722 cites W2114783294 @default.
• W2068163722 cites W2118061894 @default.
• W2068163722 cites W2118637098 @default.
• W2068163722 cites W2125797482 @default.
• W2068163722 cites W2160371936 @default.
• W2068163722 cites W232537244 @default.
• W2068163722 cites W4313347686 @default.
• W2068163722 doi "https://doi.org/10.1034/j.1600-6143.2002.020108.x" @default.
• W2068163722 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12095055" @default.
• W2068163722 hasPublicationYear "2002" @default.
• W2068163722 type Work @default.
• W2068163722 sameAs 2068163722 @default.
• W2068163722 citedByCount "11" @default.
• W2068163722 crossrefType "journal-article" @default.
• W2068163722 hasAuthorship W2068163722A5004584175 @default.
• W2068163722 hasAuthorship W2068163722A5008750595 @default.
• W2068163722 hasAuthorship W2068163722A5027563261 @default.
• W2068163722 hasAuthorship W2068163722A5052690820 @default.
• W2068163722 hasAuthorship W2068163722A5090706571 @default.
• W2068163722 hasAuthorship W2068163722A5091360661 @default.
• W2068163722 hasBestOaLocation W20681637221 @default.
• W2068163722 hasConcept C126322002 @default.
• W2068163722 hasConcept C154317977 @default.
• W2068163722 hasConcept C159654299 @default.
• W2068163722 hasConcept C202751555 @default.
• W2068163722 hasConcept C203014093 @default.
• W2068163722 hasConcept C2776090121 @default.
• W2068163722 hasConcept C2777561873 @default.
• W2068163722 hasConcept C2778740727 @default.
• W2068163722 hasConcept C2911091166 @default.
• W2068163722 hasConcept C39347974 @default.
• W2068163722 hasConcept C502942594 @default.
• W2068163722 hasConcept C542903549 @default.
• W2068163722 hasConcept C55493867 @default.
• W2068163722 hasConcept C71924100 @default.
• W2068163722 hasConcept C86803240 @default.
• W2068163722 hasConcept C8891405 @default.
• W2068163722 hasConceptScore W2068163722C126322002 @default.
• W2068163722 hasConceptScore W2068163722C154317977 @default.
• W2068163722 hasConceptScore W2068163722C159654299 @default.
• W2068163722 hasConceptScore W2068163722C202751555 @default.
• W2068163722 hasConceptScore W2068163722C203014093 @default.
• W2068163722 hasConceptScore W2068163722C2776090121 @default.
• W2068163722 hasConceptScore W2068163722C2777561873 @default.
• W2068163722 hasConceptScore W2068163722C2778740727 @default.
• W2068163722 hasConceptScore W2068163722C2911091166 @default.
• W2068163722 hasConceptScore W2068163722C39347974 @default.
• W2068163722 hasConceptScore W2068163722C502942594 @default.
• W2068163722 hasConceptScore W2068163722C542903549 @default.
• W2068163722 hasConceptScore W2068163722C55493867 @default.
• W2068163722 hasConceptScore W2068163722C71924100 @default.
• W2068163722 hasConceptScore W2068163722C86803240 @default.
• W2068163722 hasConceptScore W2068163722C8891405 @default.
• W2068163722 hasIssue "1" @default.
• W2068163722 hasLocation W20681637221 @default.
• W2068163722 hasLocation W20681637222 @default.
• W2068163722 hasOpenAccess W2068163722 @default.
• W2068163722 hasPrimaryLocation W20681637221 @default.
• W2068163722 hasRelatedWork W2014861510 @default.
• W2068163722 hasRelatedWork W2058298091 @default.
• W2068163722 hasRelatedWork W2068084502 @default.
• W2068163722 hasRelatedWork W2122584026 @default.
• W2068163722 hasRelatedWork W2139860153 @default.
• W2068163722 hasRelatedWork W2148785609 @default.

• next