Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068164877> ?p ?o ?g. }
- W2068164877 endingPage "21113" @default.
- W2068164877 startingPage "21087" @default.
- W2068164877 abstract "Carcinogenesis involves uncontrolled cell growth, which follows the activation of oncogenes and/or the deactivation of tumor suppression genes. Metastasis requires down-regulation of cell adhesion receptors necessary for tissue-specific, cell–cell attachment, as well as up-regulation of receptors that enhance cell motility. Epigenetic changes, including histone modifications, DNA methylation, and DNA hydroxymethylation, can modify these characteristics. Targets for these epigenetic changes include signaling pathways that regulate apoptosis and autophagy, as well as microRNA. We propose that predisposed normal cells convert to cancer progenitor cells that, after growing, undergo an epithelial-mesenchymal transition. This process, which is partially under epigenetic control, can create a metastatic form of both progenitor and full-fledged cancer cells, after which metastasis to a distant location may occur. Identification of epigenetic regulatory mechanisms has provided potential therapeutic avenues. In particular, epigenetic drugs appear to potentiate the action of traditional therapeutics, often by demethylating and re-expressing tumor suppressor genes to inhibit tumorigenesis. Epigenetic drugs may inhibit both the formation and growth of cancer progenitor cells, thus reducing the recurrence of cancer. Adopting epigenetic alteration as a new hallmark of cancer is a logical and necessary step that will further encourage the development of novel epigenetic biomarkers and therapeutics." @default.
- W2068164877 created "2016-06-24" @default.
- W2068164877 creator A5012128123 @default.
- W2068164877 creator A5014746268 @default.
- W2068164877 creator A5022468033 @default.
- W2068164877 creator A5039560128 @default.
- W2068164877 creator A5057998838 @default.
- W2068164877 creator A5078210165 @default.
- W2068164877 creator A5085584553 @default.
- W2068164877 date "2013-10-21" @default.
- W2068164877 modified "2023-10-17" @default.
- W2068164877 title "Cancer Development, Progression, and Therapy: An Epigenetic Overview" @default.
- W2068164877 cites W1492600479 @default.
- W2068164877 cites W1500005278 @default.
- W2068164877 cites W1504303645 @default.
- W2068164877 cites W1590850217 @default.
- W2068164877 cites W1606017238 @default.
- W2068164877 cites W1963681491 @default.
- W2068164877 cites W1963919702 @default.
- W2068164877 cites W1964150693 @default.
- W2068164877 cites W1964617786 @default.
- W2068164877 cites W1965371218 @default.
- W2068164877 cites W1967018540 @default.
- W2068164877 cites W1969929416 @default.
- W2068164877 cites W1970145665 @default.
- W2068164877 cites W1970265228 @default.
- W2068164877 cites W1971157495 @default.
- W2068164877 cites W1974182660 @default.
- W2068164877 cites W1974511713 @default.
- W2068164877 cites W1977706798 @default.
- W2068164877 cites W1977846137 @default.
- W2068164877 cites W1979522770 @default.
- W2068164877 cites W1985400766 @default.
- W2068164877 cites W1987753375 @default.
- W2068164877 cites W1989467586 @default.
- W2068164877 cites W1990369592 @default.
- W2068164877 cites W1991973226 @default.
- W2068164877 cites W1992968941 @default.
- W2068164877 cites W1993031861 @default.
- W2068164877 cites W1994049744 @default.
- W2068164877 cites W1997453048 @default.
- W2068164877 cites W1999601236 @default.
- W2068164877 cites W1999614450 @default.
- W2068164877 cites W2001258296 @default.
- W2068164877 cites W2002995168 @default.
- W2068164877 cites W2003500892 @default.
- W2068164877 cites W2005479935 @default.
- W2068164877 cites W2006797972 @default.
- W2068164877 cites W2008069197 @default.
- W2068164877 cites W2008861148 @default.
- W2068164877 cites W2010927371 @default.
- W2068164877 cites W2010984732 @default.
- W2068164877 cites W2011912935 @default.
- W2068164877 cites W2012117840 @default.
- W2068164877 cites W2012701284 @default.
- W2068164877 cites W2014623744 @default.
- W2068164877 cites W2014626044 @default.
- W2068164877 cites W2014691022 @default.
- W2068164877 cites W2016849135 @default.
- W2068164877 cites W2018189978 @default.
- W2068164877 cites W2018723470 @default.
- W2068164877 cites W2020547407 @default.
- W2068164877 cites W2023551361 @default.
- W2068164877 cites W2029409898 @default.
- W2068164877 cites W2029653385 @default.
- W2068164877 cites W2029746613 @default.
- W2068164877 cites W2031348406 @default.
- W2068164877 cites W2032882684 @default.
- W2068164877 cites W2034269086 @default.
- W2068164877 cites W2034876218 @default.
- W2068164877 cites W2038449573 @default.
- W2068164877 cites W2039213901 @default.
- W2068164877 cites W2039214381 @default.
- W2068164877 cites W2040827479 @default.
- W2068164877 cites W2045748545 @default.
- W2068164877 cites W2045842462 @default.
- W2068164877 cites W2046067852 @default.
- W2068164877 cites W2049108030 @default.
- W2068164877 cites W2049195493 @default.
- W2068164877 cites W2050031403 @default.
- W2068164877 cites W2050869737 @default.
- W2068164877 cites W2053415059 @default.
- W2068164877 cites W2053930062 @default.
- W2068164877 cites W2054147813 @default.
- W2068164877 cites W2054462619 @default.
- W2068164877 cites W2055614052 @default.
- W2068164877 cites W2056473117 @default.
- W2068164877 cites W2056802402 @default.
- W2068164877 cites W2056956799 @default.
- W2068164877 cites W2058536420 @default.
- W2068164877 cites W2062211740 @default.
- W2068164877 cites W2063698855 @default.
- W2068164877 cites W2064532505 @default.
- W2068164877 cites W2064602574 @default.
- W2068164877 cites W2066092045 @default.
- W2068164877 cites W2067656886 @default.
- W2068164877 cites W2070058781 @default.
- W2068164877 cites W2072674349 @default.