Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068166192> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2068166192 endingPage "120" @default.
- W2068166192 startingPage "114" @default.
- W2068166192 abstract "Incubation of guinea pig adrenal microsomes with 10(-6) M ferrous (Fe2+) ion and adrenal cytosol initiated high levels of lipid peroxidation as measured by the production of malonaldehyde. Cytosol or Fe2+ alone had little effect on microsomal malonaldehyde formation. When microsomes were incubated in the presence of Fe2+ and cytosol, malonaldehyde levels continued to increase for at least 60 min. Accompanying the lipid peroxidation was a decline in adrenal microsomal monooxygenase activities. The rates of metabolism of xenobiotics (benzphetamine demethylase, benzo[a]pyrene hydroxylase) as well as steroids (21-hydroxylation) decreased as malonaldehyde levels increased. In addition, cytochrome P-450 levels, NADPH- and NADH-cytochrome c reductase activities, and substrate interactions with cytochrome(s) P-450 decreased as lipid peroxidation progressed. Inhibition of lipid peroxidation by increasing microsomal protein concentrations during the incubation period prevented the changes in microsomal metabolism. Malonaldehyde had no direct effects on adrenal microsomal enzyme activities. The results indicate that lipid peroxidation may have significant effects on adrenocortical function, diminishing the capacity for both xenobiotic and steroid metabolism." @default.
- W2068166192 created "2016-06-24" @default.
- W2068166192 creator A5020168034 @default.
- W2068166192 creator A5023613168 @default.
- W2068166192 creator A5031891304 @default.
- W2068166192 date "1983-07-01" @default.
- W2068166192 modified "2023-09-27" @default.
- W2068166192 title "Effects of lipid peroxidation on adrenal microsomal monooxygenases" @default.
- W2068166192 cites W1488511002 @default.
- W2068166192 cites W1515756335 @default.
- W2068166192 cites W1775749144 @default.
- W2068166192 cites W1806194750 @default.
- W2068166192 cites W1846762578 @default.
- W2068166192 cites W18546601 @default.
- W2068166192 cites W1951469402 @default.
- W2068166192 cites W1969982879 @default.
- W2068166192 cites W1975748676 @default.
- W2068166192 cites W1988948537 @default.
- W2068166192 cites W2000934782 @default.
- W2068166192 cites W2001712555 @default.
- W2068166192 cites W2006564336 @default.
- W2068166192 cites W2014550587 @default.
- W2068166192 cites W2029882213 @default.
- W2068166192 cites W2044559504 @default.
- W2068166192 cites W2056174444 @default.
- W2068166192 cites W2069655299 @default.
- W2068166192 cites W2071877828 @default.
- W2068166192 cites W2137759070 @default.
- W2068166192 cites W2169838870 @default.
- W2068166192 cites W2174208829 @default.
- W2068166192 cites W83793659 @default.
- W2068166192 doi "https://doi.org/10.1016/0304-4165(83)90291-x" @default.
- W2068166192 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6409153" @default.
- W2068166192 hasPublicationYear "1983" @default.
- W2068166192 type Work @default.
- W2068166192 sameAs 2068166192 @default.
- W2068166192 citedByCount "13" @default.
- W2068166192 crossrefType "journal-article" @default.
- W2068166192 hasAuthorship W2068166192A5020168034 @default.
- W2068166192 hasAuthorship W2068166192A5023613168 @default.
- W2068166192 hasAuthorship W2068166192A5031891304 @default.
- W2068166192 hasConcept C115448650 @default.
- W2068166192 hasConcept C126322002 @default.
- W2068166192 hasConcept C13002179 @default.
- W2068166192 hasConcept C134018914 @default.
- W2068166192 hasConcept C181199279 @default.
- W2068166192 hasConcept C185592680 @default.
- W2068166192 hasConcept C2777606763 @default.
- W2068166192 hasConcept C2780768313 @default.
- W2068166192 hasConcept C2780829032 @default.
- W2068166192 hasConcept C2781109383 @default.
- W2068166192 hasConcept C526171541 @default.
- W2068166192 hasConcept C55493867 @default.
- W2068166192 hasConcept C62231903 @default.
- W2068166192 hasConcept C71924100 @default.
- W2068166192 hasConcept C86803240 @default.
- W2068166192 hasConcept C87644729 @default.
- W2068166192 hasConceptScore W2068166192C115448650 @default.
- W2068166192 hasConceptScore W2068166192C126322002 @default.
- W2068166192 hasConceptScore W2068166192C13002179 @default.
- W2068166192 hasConceptScore W2068166192C134018914 @default.
- W2068166192 hasConceptScore W2068166192C181199279 @default.
- W2068166192 hasConceptScore W2068166192C185592680 @default.
- W2068166192 hasConceptScore W2068166192C2777606763 @default.
- W2068166192 hasConceptScore W2068166192C2780768313 @default.
- W2068166192 hasConceptScore W2068166192C2780829032 @default.
- W2068166192 hasConceptScore W2068166192C2781109383 @default.
- W2068166192 hasConceptScore W2068166192C526171541 @default.
- W2068166192 hasConceptScore W2068166192C55493867 @default.
- W2068166192 hasConceptScore W2068166192C62231903 @default.
- W2068166192 hasConceptScore W2068166192C71924100 @default.
- W2068166192 hasConceptScore W2068166192C86803240 @default.
- W2068166192 hasConceptScore W2068166192C87644729 @default.
- W2068166192 hasIssue "2" @default.
- W2068166192 hasLocation W20681661921 @default.
- W2068166192 hasLocation W20681661922 @default.
- W2068166192 hasOpenAccess W2068166192 @default.
- W2068166192 hasPrimaryLocation W20681661921 @default.
- W2068166192 hasRelatedWork W1487825116 @default.
- W2068166192 hasRelatedWork W1586135266 @default.
- W2068166192 hasRelatedWork W1800641568 @default.
- W2068166192 hasRelatedWork W1966046198 @default.
- W2068166192 hasRelatedWork W2015694566 @default.
- W2068166192 hasRelatedWork W2058156329 @default.
- W2068166192 hasRelatedWork W2068166192 @default.
- W2068166192 hasRelatedWork W2081559087 @default.
- W2068166192 hasRelatedWork W44163912 @default.
- W2068166192 hasRelatedWork W3022933112 @default.
- W2068166192 hasVolume "758" @default.
- W2068166192 isParatext "false" @default.
- W2068166192 isRetracted "false" @default.
- W2068166192 magId "2068166192" @default.
- W2068166192 workType "article" @default.