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- W2068166251 abstract "It is well established that immune-noradrenergic reflexes and modulatory effects exerted by sympathetic nerves occur during inflammatory and immune responses. Here we studied the operation of the sympathetic nervous system (SNS) in mice infected with the intracellular parasite Trypanosoma cruzi (TC), the causal agent of Chagas’s disease, a pathology that affects millions of individuals in South and Central America. C57Bl/6J mice were infected with 100 parasites, and survival, noradrenaline (NA) content in the spleen, parasite load, and cytokines, antibodies against TC, and corticosterone blood levels were evaluated. Hundred percent lethality in males and survival of a considerable proportion of females paralleled by a reduced cytokine response, indicated a sexual dimorphism during this infection. Corticosterone blood levels were increased in mice of both sexes but were more elevated in females. There was a clear reduction in the NA content of the spleen and in the number of thyrosine hydroxylase-positive nerve fibers, an effect that was more pronounced in males than in females. To analyze the relevance of these alterations for the course of the disease, animals were chemically sympathetically denervated prior to the inoculation of the parasite. Sympathetic denervation resulted in increased parasitemia, early death of males, a significant increased lethality in females, and increased levels of IL-6, IFNγ, and IL-10, without changes in antibody levels. These studies provide further evidence for the neural control of immune and infective processes, in this case, during a parasitic infection." @default.
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- W2068166251 date "2013-02-01" @default.
- W2068166251 modified "2023-09-26" @default.
- W2068166251 title "Neural noradrenergic control of experimental Chagas’ disease" @default.
- W2068166251 doi "https://doi.org/10.1016/j.bbi.2013.01.026" @default.
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