FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068168524> ?p ?o ?g. }

• W2068168524 endingPage "1250" @default.
• W2068168524 startingPage "1245" @default.
• W2068168524 abstract "The predictive values of thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) gene expressions were retrospectively evaluated in patients with gastric cancer treated by a regimen containing S-1. The study population consisted of 53 patients registered into different two phase II studies for metastatic gastric cancer; 27 patients treated by S-1-alone study: 26 patients treated with S-1 combined with irinotecan (CPT-11). TS and DPD gene expressions in primary tumours were measured by the real-time reverse transcription PCR method. There was no statistical difference in DPD gene expression in terms of response in cases treated with S-1 alone and those treated with S-1 plus CPT-11. TS mRNA of responding tumours was lower than that of nonresponding ones when treated with S-1 (P<0.005). In the S-1-alone group, taking TS cutoff as the median values, the response rate in the low TS group was 50%, but only 8% in the high TS group (P<0.05). Patients with low TS gene expression survived longer than those with high TS gene expression (P<0.0001). However, there was no statistically significant difference in response rate and survival between patients with low TS tumours and those with high TS tumours, when the cutoff was taken as the median value of TS gene expression in the group treated with S-1 plus CPT-11. In conclusion, treatment effects of S-1 monotherapy for gastric cancer were determined by the status of TS gene expression, regardless of DPD gene expression. TS predictive power was overcome by CPT-11 combination therapy with S-1." @default.
• W2068168524 created "2016-06-24" @default.
• W2068168524 creator A5000738181 @default.
• W2068168524 creator A5008014743 @default.
• W2068168524 creator A5047958905 @default.
• W2068168524 creator A5051763335 @default.
• W2068168524 creator A5065402521 @default.
• W2068168524 creator A5065468368 @default.
• W2068168524 creator A5070720013 @default.
• W2068168524 creator A5076349434 @default.
• W2068168524 creator A5080047646 @default.
• W2068168524 date "2004-08-31" @default.
• W2068168524 modified "2023-10-07" @default.
• W2068168524 title "Thymidylate synthase predictive power is overcome by irinotecan combination therapy with S-1 for gastric cancer" @default.
• W2068168524 cites W1488985726 @default.
• W2068168524 cites W1507760891 @default.
• W2068168524 cites W1542163462 @default.
• W2068168524 cites W1751651908 @default.
• W2068168524 cites W1823160408 @default.
• W2068168524 cites W1927999720 @default.
• W2068168524 cites W1993875123 @default.
• W2068168524 cites W1996285570 @default.
• W2068168524 cites W2001736991 @default.
• W2068168524 cites W200233776 @default.
• W2068168524 cites W2008575122 @default.
• W2068168524 cites W2017800701 @default.
• W2068168524 cites W2018619890 @default.
• W2068168524 cites W2023241123 @default.
• W2068168524 cites W2026554582 @default.
• W2068168524 cites W2048231138 @default.
• W2068168524 cites W2053476076 @default.
• W2068168524 cites W2068225833 @default.
• W2068168524 cites W2071092546 @default.
• W2068168524 cites W2077902459 @default.
• W2068168524 cites W2089310103 @default.
• W2068168524 cites W2097303718 @default.
• W2068168524 cites W2099448448 @default.
• W2068168524 cites W2100688168 @default.
• W2068168524 cites W2112944030 @default.
• W2068168524 cites W2116846790 @default.
• W2068168524 cites W2125202527 @default.
• W2068168524 cites W2141735368 @default.
• W2068168524 cites W2608027589 @default.
• W2068168524 cites W61003746 @default.
• W2068168524 doi "https://doi.org/10.1038/sj.bjc.6602139" @default.
• W2068168524 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2409894" @default.
• W2068168524 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15354215" @default.
• W2068168524 hasPublicationYear "2004" @default.
• W2068168524 type Work @default.
• W2068168524 sameAs 2068168524 @default.
• W2068168524 citedByCount "76" @default.
• W2068168524 countsByYear W20681685242012 @default.
• W2068168524 countsByYear W20681685242013 @default.
• W2068168524 countsByYear W20681685242014 @default.
• W2068168524 countsByYear W20681685242015 @default.
• W2068168524 countsByYear W20681685242016 @default.
• W2068168524 countsByYear W20681685242017 @default.
• W2068168524 countsByYear W20681685242018 @default.
• W2068168524 countsByYear W20681685242019 @default.
• W2068168524 countsByYear W20681685242020 @default.
• W2068168524 countsByYear W20681685242021 @default.
• W2068168524 countsByYear W20681685242023 @default.
• W2068168524 crossrefType "journal-article" @default.
• W2068168524 hasAuthorship W2068168524A5000738181 @default.
• W2068168524 hasAuthorship W2068168524A5008014743 @default.
• W2068168524 hasAuthorship W2068168524A5047958905 @default.
• W2068168524 hasAuthorship W2068168524A5051763335 @default.
• W2068168524 hasAuthorship W2068168524A5065402521 @default.
• W2068168524 hasAuthorship W2068168524A5065468368 @default.
• W2068168524 hasAuthorship W2068168524A5070720013 @default.
• W2068168524 hasAuthorship W2068168524A5076349434 @default.
• W2068168524 hasAuthorship W2068168524A5080047646 @default.
• W2068168524 hasBestOaLocation W20681685241 @default.
• W2068168524 hasConcept C104317684 @default.
• W2068168524 hasConcept C121608353 @default.
• W2068168524 hasConcept C123321153 @default.
• W2068168524 hasConcept C126322002 @default.
• W2068168524 hasConcept C143998085 @default.
• W2068168524 hasConcept C150194340 @default.
• W2068168524 hasConcept C2778050828 @default.
• W2068168524 hasConcept C2780259306 @default.
• W2068168524 hasConcept C2780456651 @default.
• W2068168524 hasConcept C526805850 @default.
• W2068168524 hasConcept C55493867 @default.
• W2068168524 hasConcept C71924100 @default.
• W2068168524 hasConcept C86803240 @default.
• W2068168524 hasConcept C90924648 @default.
• W2068168524 hasConceptScore W2068168524C104317684 @default.
• W2068168524 hasConceptScore W2068168524C121608353 @default.
• W2068168524 hasConceptScore W2068168524C123321153 @default.
• W2068168524 hasConceptScore W2068168524C126322002 @default.
• W2068168524 hasConceptScore W2068168524C143998085 @default.
• W2068168524 hasConceptScore W2068168524C150194340 @default.
• W2068168524 hasConceptScore W2068168524C2778050828 @default.
• W2068168524 hasConceptScore W2068168524C2780259306 @default.
• W2068168524 hasConceptScore W2068168524C2780456651 @default.
• W2068168524 hasConceptScore W2068168524C526805850 @default.
• W2068168524 hasConceptScore W2068168524C55493867 @default.

• next