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- W2068169035 abstract "A novel series of 4-substituted 1-{[4-(10,15,20-triphenylporphyrin-5-yl)phenyl]methylidene}thiosemicarbazide, 4a–4n, was synthesized in 9–21% yield by the condensation of 4-(10,15,20-triphenylporphyrin-5-yl)benzaldehyde (3) with various substituted thiosemicarbazides in presence of catalytic amount of AcOH. These compounds were assayed for in vitro antiamoebic activity, and the results showed that out of 14 compounds 9 were found with IC50 values lower than metronidazole corresponding to 1.05- to 4.7-fold increase in activity. MTT Assay showed that all the compounds are nontoxic to human kidney epithelial cell line. 4-(m-Toluidinyl)-1-{[4-(10,15,20-triphenylporphyrin-5-yl)phenyl]methylidene}thiosemicarbazide (4h) showed the highest antiamoebic activity with least cytotoxicity. Some of the compounds were screened for their antimalarial activities and ability to inhibit β-haematin formation, but none of them showed an activity better than chloroquine and quinine. Only one compound out of six showed an activity comparable to standard drug." @default.
- W2068169035 created "2016-06-24" @default.
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- W2068169035 date "2008-05-01" @default.
- W2068169035 modified "2023-10-18" @default.
- W2068169035 title "Synthesis and Biological Evaluation of Novel 4-Substituted 1-{[4-(10,15,20-Triphenylporphyrin-5-yl)phenyl]methylidene}thiosemicarbazides as New Class of Potential Antiprotozoal Agents" @default.
- W2068169035 cites W1567609230 @default.
- W2068169035 cites W1964315121 @default.
- W2068169035 cites W1964498810 @default.
- W2068169035 cites W1964605416 @default.
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- W2068169035 cites W1972256499 @default.
- W2068169035 cites W1975011967 @default.
- W2068169035 cites W1977213067 @default.
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- W2068169035 cites W2001682404 @default.
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- W2068169035 cites W2014594775 @default.
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- W2068169035 cites W2025055766 @default.
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- W2068169035 doi "https://doi.org/10.1002/cbdv.200890073" @default.
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