Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068173500> ?p ?o ?g. }
- W2068173500 endingPage "10962" @default.
- W2068173500 startingPage "10951" @default.
- W2068173500 abstract "We report on the molecular cloning of a novel human cDNA by its interaction with the splicing factor SRp30c in a yeast two-hybrid screen. This cDNA is predominantly expressed in muscle and encodes a protein that is present in the nucleoplasm and concentrated in nucleoli. It was therefore termed Nop30 (nucleolar protein of 30 kDa). We have also identified a related cDNA with a different carboxyl terminus. Sequencing of the NOP gene demonstrated that both cDNAs are generated by alternative 5' splice site usage from a single gene that consists of four exons, spans at least 1800 nucleotides, and is located on chromosome 16q21-q23. The alternative 5' splice site usage introduces a frameshift creating two different carboxyl termini. The carboxyl terminus of Nop30 is rich in serines and arginines and has been found to target the protein into the nucleus, whereas its isoform is characterized by proline/glutamic acid dipeptides in its carboxyl terminus and is predominantly found in the cytosol. Interaction studies in yeast, in vitro protein interaction assays, and co-immunoprecipitations demonstrated that Nop30 multimerizes and binds to the RS domain of SRp30c but not to other splicing factors tested. Overexpression of Nop30 changes alternative exon usage in preprotachykinin and SRp20 reporter genes, suggesting that Nop30 influences alternative splice site selection in vivo." @default.
- W2068173500 created "2016-06-24" @default.
- W2068173500 creator A5013019099 @default.
- W2068173500 creator A5041074022 @default.
- W2068173500 creator A5043599144 @default.
- W2068173500 creator A5067366264 @default.
- W2068173500 date "1999-04-01" @default.
- W2068173500 modified "2023-10-12" @default.
- W2068173500 title "Alternative Splicing Determines the Intracellular Localization of the Novel Nuclear Protein Nop30 and Its Interaction with the Splicing Factor SRp30c" @default.
- W2068173500 cites W1507547708 @default.
- W2068173500 cites W152405475 @default.
- W2068173500 cites W1549854583 @default.
- W2068173500 cites W1681431349 @default.
- W2068173500 cites W1812729869 @default.
- W2068173500 cites W1951293977 @default.
- W2068173500 cites W1964795768 @default.
- W2068173500 cites W1966123525 @default.
- W2068173500 cites W1975797969 @default.
- W2068173500 cites W1977186059 @default.
- W2068173500 cites W1979782947 @default.
- W2068173500 cites W1985669469 @default.
- W2068173500 cites W1995766918 @default.
- W2068173500 cites W1996468935 @default.
- W2068173500 cites W2004284423 @default.
- W2068173500 cites W2009105413 @default.
- W2068173500 cites W2010841319 @default.
- W2068173500 cites W2012640439 @default.
- W2068173500 cites W2020711042 @default.
- W2068173500 cites W2023916002 @default.
- W2068173500 cites W2024267851 @default.
- W2068173500 cites W2025863850 @default.
- W2068173500 cites W2027004224 @default.
- W2068173500 cites W2042833699 @default.
- W2068173500 cites W2050110567 @default.
- W2068173500 cites W2054084236 @default.
- W2068173500 cites W2055189297 @default.
- W2068173500 cites W2059177755 @default.
- W2068173500 cites W2062181102 @default.
- W2068173500 cites W2063225252 @default.
- W2068173500 cites W2063887644 @default.
- W2068173500 cites W2066917897 @default.
- W2068173500 cites W2068719237 @default.
- W2068173500 cites W2069252364 @default.
- W2068173500 cites W2071152718 @default.
- W2068173500 cites W2071336621 @default.
- W2068173500 cites W2076701374 @default.
- W2068173500 cites W2079194595 @default.
- W2068173500 cites W2081978672 @default.
- W2068173500 cites W2082127202 @default.
- W2068173500 cites W2082491111 @default.
- W2068173500 cites W2084503797 @default.
- W2068173500 cites W2100837269 @default.
- W2068173500 cites W2104788940 @default.
- W2068173500 cites W2119952251 @default.
- W2068173500 cites W2124620276 @default.
- W2068173500 cites W2142210692 @default.
- W2068173500 cites W2146761087 @default.
- W2068173500 cites W215272066 @default.
- W2068173500 cites W2156762274 @default.
- W2068173500 cites W2165477701 @default.
- W2068173500 cites W2186312706 @default.
- W2068173500 cites W4251695548 @default.
- W2068173500 cites W48376435 @default.
- W2068173500 doi "https://doi.org/10.1074/jbc.274.16.10951" @default.
- W2068173500 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10196175" @default.
- W2068173500 hasPublicationYear "1999" @default.
- W2068173500 type Work @default.
- W2068173500 sameAs 2068173500 @default.
- W2068173500 citedByCount "37" @default.
- W2068173500 countsByYear W20681735002012 @default.
- W2068173500 countsByYear W20681735002015 @default.
- W2068173500 countsByYear W20681735002016 @default.
- W2068173500 countsByYear W20681735002019 @default.
- W2068173500 countsByYear W20681735002020 @default.
- W2068173500 countsByYear W20681735002021 @default.
- W2068173500 countsByYear W20681735002022 @default.
- W2068173500 countsByYear W20681735002023 @default.
- W2068173500 crossrefType "journal-article" @default.
- W2068173500 hasAuthorship W2068173500A5013019099 @default.
- W2068173500 hasAuthorship W2068173500A5041074022 @default.
- W2068173500 hasAuthorship W2068173500A5043599144 @default.
- W2068173500 hasAuthorship W2068173500A5067366264 @default.
- W2068173500 hasBestOaLocation W20681735001 @default.
- W2068173500 hasConcept C104317684 @default.
- W2068173500 hasConcept C10447831 @default.
- W2068173500 hasConcept C185592680 @default.
- W2068173500 hasConcept C194583182 @default.
- W2068173500 hasConcept C36823959 @default.
- W2068173500 hasConcept C42576000 @default.
- W2068173500 hasConcept C54458228 @default.
- W2068173500 hasConcept C55493867 @default.
- W2068173500 hasConcept C67705224 @default.
- W2068173500 hasConcept C69551769 @default.
- W2068173500 hasConcept C70721500 @default.
- W2068173500 hasConcept C73758832 @default.
- W2068173500 hasConcept C79879829 @default.
- W2068173500 hasConcept C86803240 @default.
- W2068173500 hasConcept C95444343 @default.