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- W2068176768 abstract "The equilibrium binding constants of [3H]Ro 5-4864 (a peripheral benzodiazepine receptor ligand) to renal membranes preserved by various freezing techniques were investigated. The Bmax for [3H]Ro 5-4864 binding to membranes from kidneys preserved as unwashed homogenates stored at -80, -20, or 5 degrees C, whole kidneys stores at -20 or 5 degrees C or as washed homogenate stored at -20 degrees C was significantly decreased (approximately 35%). Only when kidneys were frozen intact (using a dry-ice/acetone slurry) and stored at -80 degrees C was the density of [3H]Ro 5-4864 binding unchanged. However, the Bmax of [3H]PK 11195 (a putative peripheral benzodiazepine receptor antagonist) binding to renal membranes was unchanged following storage techniques that reduced the density of [3H]Ro 5-4864 binding 38%. No change was observed in the Kd values for [3H]Ro 5-4864 and [3H]PK 11195 binding to renal membranes preserved under any condition tested. These results demonstrate a method for the preservation of [3H]Ro 5-4864 binding to renal membranes, and suggests that [3H]Ro 5-4864 and [3H]PK 11195 bind to unique sites on or near the peripheral benzodiazepine receptor. [corrected]" @default.
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- W2068176768 date "1987-04-01" @default.
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- W2068176768 title "Preservation of “peripheral” benzodiazepine receptors: Differential effects of freezing on [3H]Ro 5-4864 and [3H]PK 11195 binding" @default.
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- W2068176768 doi "https://doi.org/10.1016/0160-5402(87)90025-8" @default.
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