FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068179105> ?p ?o ?g. }

• W2068179105 endingPage "1220" @default.
• W2068179105 startingPage "1213" @default.
• W2068179105 abstract "To enhance the efficacy of fenretinide (4HPR)-induced reactive oxygen species (ROS) in neuroblastoma, 4HPR was combined with buthionine sulfoximine (BSO), an inhibitor of glutathione (GSH) synthesis, in neuroblastoma cell lines and spheroids, the latter being a three-dimensional tumor model. 4HPR exposure (2.5-10 μM, 24 h) resulted in ROS induction (114-633%) and increased GSH levels (68-120%). A GSH depletion of 80% of basal levels was observed in the presence of BSO (25-100 μM, 24 h). The 4HPR-BSO combination resulted in slightly increased ROS levels (1.1- to 1.3-fold) accompanied by an increase in cytotoxicity (110-150%) compared to 4HPR treatment alone. A correlation was observed between the ROS-inducing capacity of each cell line and the increase in cytotoxicity induced by 4HPR-BSO compared to 4HPR. No significant correlation between baseline antioxidant levels and sensitivity to 4HPR or BSO was observed. In spheroids, 4HPR-BSO induced a strong synergistic growth retardation and induction of apoptosis. Our data show that BSO increased the cytotoxic effects of 4HPR in neuroblastoma monolayers and spheroids in ROS-producing cell lines. This indicates that the 4HPR-BSO combination might be a promising new strategy in the treatment of neuroblastoma." @default.
• W2068179105 created "2016-06-24" @default.
• W2068179105 creator A5014498949 @default.
• W2068179105 creator A5056025258 @default.
• W2068179105 creator A5057873409 @default.
• W2068179105 creator A5072840045 @default.
• W2068179105 creator A5079496433 @default.
• W2068179105 creator A5089588265 @default.
• W2068179105 date "2011-09-01" @default.
• W2068179105 modified "2023-10-16" @default.
• W2068179105 title "Promising effects of the 4HPR–BSO combination in neuroblastoma monolayers and spheroids" @default.
• W2068179105 cites W1604239499 @default.
• W2068179105 cites W1857262284 @default.
• W2068179105 cites W1974726571 @default.
• W2068179105 cites W1975085998 @default.
• W2068179105 cites W1975225745 @default.
• W2068179105 cites W1978483995 @default.
• W2068179105 cites W1979850497 @default.
• W2068179105 cites W2001407902 @default.
• W2068179105 cites W2007064404 @default.
• W2068179105 cites W2011078573 @default.
• W2068179105 cites W2022734286 @default.
• W2068179105 cites W2031999073 @default.
• W2068179105 cites W2033457512 @default.
• W2068179105 cites W2035640329 @default.
• W2068179105 cites W2036670186 @default.
• W2068179105 cites W2039779394 @default.
• W2068179105 cites W2041762658 @default.
• W2068179105 cites W2046174392 @default.
• W2068179105 cites W2057093367 @default.
• W2068179105 cites W2062465964 @default.
• W2068179105 cites W2076590791 @default.
• W2068179105 cites W2084015464 @default.
• W2068179105 cites W2086705375 @default.
• W2068179105 cites W2102992436 @default.
• W2068179105 cites W2108228283 @default.
• W2068179105 cites W2110742957 @default.
• W2068179105 cites W2123898564 @default.
• W2068179105 cites W2129713736 @default.
• W2068179105 cites W2169711907 @default.
• W2068179105 cites W2328514608 @default.
• W2068179105 cites W2417253317 @default.
• W2068179105 cites W4245957869 @default.
• W2068179105 doi "https://doi.org/10.1016/j.freeradbiomed.2011.06.019" @default.
• W2068179105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21741474" @default.
• W2068179105 hasPublicationYear "2011" @default.
• W2068179105 type Work @default.
• W2068179105 sameAs 2068179105 @default.
• W2068179105 citedByCount "8" @default.
• W2068179105 countsByYear W20681791052012 @default.
• W2068179105 countsByYear W20681791052013 @default.
• W2068179105 countsByYear W20681791052014 @default.
• W2068179105 countsByYear W20681791052015 @default.
• W2068179105 countsByYear W20681791052016 @default.
• W2068179105 countsByYear W20681791052019 @default.
• W2068179105 countsByYear W20681791052021 @default.
• W2068179105 crossrefType "journal-article" @default.
• W2068179105 hasAuthorship W2068179105A5014498949 @default.
• W2068179105 hasAuthorship W2068179105A5056025258 @default.
• W2068179105 hasAuthorship W2068179105A5057873409 @default.
• W2068179105 hasAuthorship W2068179105A5072840045 @default.
• W2068179105 hasAuthorship W2068179105A5079496433 @default.
• W2068179105 hasAuthorship W2068179105A5089588265 @default.
• W2068179105 hasConcept C104317684 @default.
• W2068179105 hasConcept C109316439 @default.
• W2068179105 hasConcept C134018914 @default.
• W2068179105 hasConcept C154317977 @default.
• W2068179105 hasConcept C175369904 @default.
• W2068179105 hasConcept C181199279 @default.
• W2068179105 hasConcept C185592680 @default.
• W2068179105 hasConcept C190283241 @default.
• W2068179105 hasConcept C202751555 @default.
• W2068179105 hasConcept C2775954498 @default.
• W2068179105 hasConcept C2776715637 @default.
• W2068179105 hasConcept C2777476445 @default.
• W2068179105 hasConcept C2780533455 @default.
• W2068179105 hasConcept C2781121885 @default.
• W2068179105 hasConcept C48349386 @default.
• W2068179105 hasConcept C502942594 @default.
• W2068179105 hasConcept C538909803 @default.
• W2068179105 hasConcept C54355233 @default.
• W2068179105 hasConcept C55493867 @default.
• W2068179105 hasConcept C81885089 @default.
• W2068179105 hasConcept C86803240 @default.
• W2068179105 hasConceptScore W2068179105C104317684 @default.
• W2068179105 hasConceptScore W2068179105C109316439 @default.
• W2068179105 hasConceptScore W2068179105C134018914 @default.
• W2068179105 hasConceptScore W2068179105C154317977 @default.
• W2068179105 hasConceptScore W2068179105C175369904 @default.
• W2068179105 hasConceptScore W2068179105C181199279 @default.
• W2068179105 hasConceptScore W2068179105C185592680 @default.
• W2068179105 hasConceptScore W2068179105C190283241 @default.
• W2068179105 hasConceptScore W2068179105C202751555 @default.
• W2068179105 hasConceptScore W2068179105C2775954498 @default.
• W2068179105 hasConceptScore W2068179105C2776715637 @default.
• W2068179105 hasConceptScore W2068179105C2777476445 @default.
• W2068179105 hasConceptScore W2068179105C2780533455 @default.
• W2068179105 hasConceptScore W2068179105C2781121885 @default.

• next