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- W2068184472 abstract "Antigen-specific T cell recognition is dependent on the functional density of the TCR-ligand, which consists of specific MHC molecules and a specifically bound peptide. We have examined the influence of the affinity and concentration of exogenous peptide and the density of specific MHC molecules on the proliferation of a CD4+, DQA1*0501/DQB1*0201 (DQ2.1)-restricted, HSV-2-specific T cell clone. Using antigen peptide analogs with different mutations of known DQ2-anchor residues, T cell response was reduced in an peptide-affinity and - concentration specific manner. The decrease using weaker binding peptides was gradual as stimulation with a peptide with intermediate affinity yielded intermediate T cell proliferation and the poorest binding peptide induced an even weaker T cell response. MHC class II density on the APC was modified using DQ2 homo- and heterozygous B-LCLs as APCs, however this variation of MHC concentration had no effect on T cell proliferation. We interpret this as a reflection of a low threshold for activation of the T cell clone, in which peptide-MHC avidity is the over-riding determinant of the strength of ligand signal." @default.
- W2068184472 created "2016-06-24" @default.
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- W2068184472 date "1999-07-01" @default.
- W2068184472 modified "2023-10-17" @default.
- W2068184472 title "MHC-peptide ligand interactions establish a functional threshold for antigen-specific T cell recognition" @default.
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- W2068184472 doi "https://doi.org/10.1016/s0198-8859(99)00038-5" @default.
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