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- W2068185636 abstract "Tyrosine hydroxylation in the rat striatum was determined by measuring the formation of tritiated water from 3H-3,5-tyrosine in vitro and the accumulation of 14C-dopamine formed from i.v. administered 14C-tyrosine in vivo. Pour days after a unilateral lesion of the nigro-striatal dopamine pathway, the in vitro tyrosine hydroxylase activity of the striatum on the lesioned side was reduced to about 10 % of that on the intact side. The accumulation of 14C-dopamine formed in vivo from 14C-tyrosine was reduced to about 25%. Following both acute and chronic chlorpromazine treatment of unlesioned rats, the accumulation of labelled dopamine, formed from 14C-tyrosine in the striatum, was doubled. However, neither acute nor chronic drug treatment altered significantly the tyrosine hydroxylase activity. The results are taken as evidence that the acceleration of dopamine synthesis in the striatum following chlorpromazine is mediated predominantly through other mechanisms than induction of tyrosine hydroxylase." @default.
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- W2068185636 date "1972-07-01" @default.
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- W2068185636 title "Tyrosine hydroxylation in the rat striatum in vitro and vivo after nigral lesion and chlorpromazine treatment" @default.
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