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- W2068186346 abstract "Metaphase cells accumulate in HeLa and Vero cultures exposed in G2 to cordycepin (3′deoxyadenosine, 3′dA) at doses of 25–100 μg/ml. The arrested cells have small spindle zones and reduced numbers of interpolar or non-chromosomal spindle microtubules. While these concentrations of 3′dA have been used to suppress mRNA synthesis, the mitotic arrest does not appear to result from inhibition of RNA synthesis. Synchronized Vero cells treated in G2 with sufficient concentrations of actinomycin D to suppress transcription of virtually all RNA do not subsequently become arrested in mitosis. It is proposed that cordycepin interferes with the formation or normal functioning of the mitotic spindle. The microtubules of interphase cells may also be affected by cordycepin. The amount of microtubular crystals formed after exposure of several different cell types to vinblastine sulfate is markedly reduced after pretreatment with cordycepin." @default.
- W2068186346 created "2016-06-24" @default.
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- W2068186346 date "1979-01-01" @default.
- W2068186346 modified "2023-09-24" @default.
- W2068186346 title "Effects of cordycepin on microtubules of cultured mammalian cells" @default.
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- W2068186346 doi "https://doi.org/10.1016/0014-4827(79)90577-9" @default.
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