FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068188634> ?p ?o ?g. }

• W2068188634 endingPage "42" @default.
• W2068188634 startingPage "29" @default.
• W2068188634 abstract "Liver fibrosis (LF), where the chronic HCV infection is a major cause, is a characteristic of chronic liver diseases. LF results from chronic damage to the liver in conjunction with the accumulation of ECM proteins. Matrix metalloproteinases (MMPs) and their specific inhibitors (TIMPs) are thought to play an essential role in the hepatic lesions. The available data concerning the circulating levels of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in chronic hepatitis C are not conclusive. Therefore, the present study was designed to seek the relationship between serum MMP-9, and TIMP-1 to liver status in chronic liver disease in fifty patients divided into three groups (chronic hepatitis, liver cirrhosis and hepatocellular carcinoma). MMP-9 and TIMP-1 were analyzed by the enzyme linked immunosorbent assay (ELISA). The results showed that the lowest serum level of MMP-9 was found in chronic hepatitis patients compared to the control ( P < 0.05). Serum MMP-9 is decreasing during progression of chronic hepatitis to cirrhosis showing the least level in the cirrhotic group. Serum TIMP-1 was significantly higher in the cirrhotic group compared to chronic hepatitis ( P < 0.05) and controls ( P < 0.001). MMP-9 was negatively correlated to both TIMP-1 and the histological severity in chronic hepatitis. There was a positive correlation between TIMP-1 and the degree of fibrosis (r = 0.73, P < 0.001). Lastly, there was a statistically significant increase of MMP-9 ( P < 0.001) and TIMP-1 ( P < 0.05) in HCC patients compared with the other groups. In conclusion, these findings raise the possibility of using serum TIMP-1 as a non-invasive assay in liver fibrosis. Further, the altered balance between circulating MMP-9 and TIMP-1 during HCV infection may play an important role in aggravating liver injury progression in chronic liver diseases." @default.
• W2068188634 created "2016-06-24" @default.
• W2068188634 creator A5004715836 @default.
• W2068188634 creator A5033567199 @default.
• W2068188634 creator A5039129858 @default.
• W2068188634 creator A5056206373 @default.
• W2068188634 creator A5057121275 @default.
• W2068188634 creator A5059713001 @default.
• W2068188634 creator A5072428595 @default.
• W2068188634 date "2010-03-01" @default.
• W2068188634 modified "2023-09-27" @default.
• W2068188634 title "Significance of serum matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in chronic hepatitis C patients" @default.
• W2068188634 cites W117859416 @default.
• W2068188634 cites W1548479200 @default.
• W2068188634 cites W1587896012 @default.
• W2068188634 cites W1591664409 @default.
• W2068188634 cites W1944256851 @default.
• W2068188634 cites W1972689256 @default.
• W2068188634 cites W1981900811 @default.
• W2068188634 cites W1988646738 @default.
• W2068188634 cites W1996610886 @default.
• W2068188634 cites W2004508940 @default.
• W2068188634 cites W2025817084 @default.
• W2068188634 cites W2028626004 @default.
• W2068188634 cites W2031732449 @default.
• W2068188634 cites W2038191207 @default.
• W2068188634 cites W2047721047 @default.
• W2068188634 cites W2056336336 @default.
• W2068188634 cites W2072103796 @default.
• W2068188634 cites W2104187124 @default.
• W2068188634 cites W2105574411 @default.
• W2068188634 cites W2153055943 @default.
• W2068188634 cites W2154870951 @default.
• W2068188634 cites W4235022528 @default.
• W2068188634 cites W4240409061 @default.
• W2068188634 cites W4246577885 @default.
• W2068188634 cites W4256484569 @default.
• W2068188634 cites W2021361172 @default.
• W2068188634 doi "https://doi.org/10.1556/amicr.57.2010.1.3" @default.
• W2068188634 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20350877" @default.
• W2068188634 hasPublicationYear "2010" @default.
• W2068188634 type Work @default.
• W2068188634 sameAs 2068188634 @default.
• W2068188634 citedByCount "30" @default.
• W2068188634 countsByYear W20681886342012 @default.
• W2068188634 countsByYear W20681886342013 @default.
• W2068188634 countsByYear W20681886342014 @default.
• W2068188634 countsByYear W20681886342015 @default.
• W2068188634 countsByYear W20681886342016 @default.
• W2068188634 countsByYear W20681886342017 @default.
• W2068188634 countsByYear W20681886342018 @default.
• W2068188634 countsByYear W20681886342020 @default.
• W2068188634 countsByYear W20681886342021 @default.
• W2068188634 countsByYear W20681886342022 @default.
• W2068188634 crossrefType "journal-article" @default.
• W2068188634 hasAuthorship W2068188634A5004715836 @default.
• W2068188634 hasAuthorship W2068188634A5033567199 @default.
• W2068188634 hasAuthorship W2068188634A5039129858 @default.
• W2068188634 hasAuthorship W2068188634A5056206373 @default.
• W2068188634 hasAuthorship W2068188634A5057121275 @default.
• W2068188634 hasAuthorship W2068188634A5059713001 @default.
• W2068188634 hasAuthorship W2068188634A5072428595 @default.
• W2068188634 hasConcept C109523444 @default.
• W2068188634 hasConcept C126322002 @default.
• W2068188634 hasConcept C142724271 @default.
• W2068188634 hasConcept C203014093 @default.
• W2068188634 hasConcept C2522874641 @default.
• W2068188634 hasConcept C2775965246 @default.
• W2068188634 hasConcept C2776029263 @default.
• W2068188634 hasConcept C2776455275 @default.
• W2068188634 hasConcept C2777214474 @default.
• W2068188634 hasConcept C2778019345 @default.
• W2068188634 hasConcept C2779102576 @default.
• W2068188634 hasConcept C2780559512 @default.
• W2068188634 hasConcept C3020491458 @default.
• W2068188634 hasConcept C55728118 @default.
• W2068188634 hasConcept C71924100 @default.
• W2068188634 hasConcept C90924648 @default.
• W2068188634 hasConceptScore W2068188634C109523444 @default.
• W2068188634 hasConceptScore W2068188634C126322002 @default.
• W2068188634 hasConceptScore W2068188634C142724271 @default.
• W2068188634 hasConceptScore W2068188634C203014093 @default.
• W2068188634 hasConceptScore W2068188634C2522874641 @default.
• W2068188634 hasConceptScore W2068188634C2775965246 @default.
• W2068188634 hasConceptScore W2068188634C2776029263 @default.
• W2068188634 hasConceptScore W2068188634C2776455275 @default.
• W2068188634 hasConceptScore W2068188634C2777214474 @default.
• W2068188634 hasConceptScore W2068188634C2778019345 @default.
• W2068188634 hasConceptScore W2068188634C2779102576 @default.
• W2068188634 hasConceptScore W2068188634C2780559512 @default.
• W2068188634 hasConceptScore W2068188634C3020491458 @default.
• W2068188634 hasConceptScore W2068188634C55728118 @default.
• W2068188634 hasConceptScore W2068188634C71924100 @default.
• W2068188634 hasConceptScore W2068188634C90924648 @default.
• W2068188634 hasIssue "1" @default.
• W2068188634 hasLocation W20681886341 @default.
• W2068188634 hasLocation W20681886342 @default.
• W2068188634 hasOpenAccess W2068188634 @default.

• next