FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068193025> ?p ?o ?g. }

• W2068193025 endingPage "228" @default.
• W2068193025 startingPage "225" @default.
• W2068193025 abstract "Starvation and Autophagy Starvation stimulates withdrawal from the cell cycle, as well as stimulating autophagy. Are these two events connected? Lee et al. (p. 225 ) show a direct and nutrient-sensitive interaction between the tumor suppressor p53 and the essential autophagy gene Atg7. Further, in the absence of Atg7, the p53-dependent induction of the cyclin-dependent kinase inhibitor p21 is inhibited. This leads to Atg7-deficient cells being unable to properly withdraw from the cell cycle under starved conditions. While Atg7 deletion leads to an impairment of p53-mediated cell-cycle arrest, the Atg7-deficient cells hyperactivate p53-mediated cell-death pathways. The physiological importance of this hyperactivation is underscored by the observation that genetic blocking of p53-mediated cell death significantly extended neonatal survival of mice in which Atg7 had been deleted." @default.
• W2068193025 created "2016-06-24" @default.
• W2068193025 creator A5005230969 @default.
• W2068193025 creator A5011179194 @default.
• W2068193025 creator A5014670369 @default.
• W2068193025 creator A5021881572 @default.
• W2068193025 creator A5022120877 @default.
• W2068193025 creator A5053967338 @default.
• W2068193025 creator A5069932874 @default.
• W2068193025 creator A5088481321 @default.
• W2068193025 date "2012-04-13" @default.
• W2068193025 modified "2023-10-17" @default.
• W2068193025 title "Atg7 Modulates p53 Activity to Regulate Cell Cycle and Survival During Metabolic Stress" @default.
• W2068193025 cites W1970472050 @default.
• W2068193025 cites W1973190082 @default.
• W2068193025 cites W1984943445 @default.
• W2068193025 cites W1992516982 @default.
• W2068193025 cites W2007743440 @default.
• W2068193025 cites W2015519364 @default.
• W2068193025 cites W2019630846 @default.
• W2068193025 cites W2022812113 @default.
• W2068193025 cites W2023623233 @default.
• W2068193025 cites W2028044172 @default.
• W2068193025 cites W2028459159 @default.
• W2068193025 cites W2037646515 @default.
• W2068193025 cites W2039607936 @default.
• W2068193025 cites W2042461504 @default.
• W2068193025 cites W2059171668 @default.
• W2068193025 cites W2065864183 @default.
• W2068193025 cites W2085442981 @default.
• W2068193025 cites W2089218510 @default.
• W2068193025 cites W2090563156 @default.
• W2068193025 cites W2102614059 @default.
• W2068193025 cites W2106255061 @default.
• W2068193025 cites W2109569600 @default.
• W2068193025 cites W2110025151 @default.
• W2068193025 cites W2146887271 @default.
• W2068193025 cites W2148964728 @default.
• W2068193025 cites W2150027419 @default.
• W2068193025 cites W2153463588 @default.
• W2068193025 cites W2157921578 @default.
• W2068193025 cites W2163147674 @default.
• W2068193025 cites W2164698768 @default.
• W2068193025 doi "https://doi.org/10.1126/science.1218395" @default.
• W2068193025 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4721513" @default.
• W2068193025 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22499945" @default.
• W2068193025 hasPublicationYear "2012" @default.
• W2068193025 type Work @default.
• W2068193025 sameAs 2068193025 @default.
• W2068193025 citedByCount "271" @default.
• W2068193025 countsByYear W20681930252012 @default.
• W2068193025 countsByYear W20681930252013 @default.
• W2068193025 countsByYear W20681930252014 @default.
• W2068193025 countsByYear W20681930252015 @default.
• W2068193025 countsByYear W20681930252016 @default.
• W2068193025 countsByYear W20681930252017 @default.
• W2068193025 countsByYear W20681930252018 @default.
• W2068193025 countsByYear W20681930252019 @default.
• W2068193025 countsByYear W20681930252020 @default.
• W2068193025 countsByYear W20681930252021 @default.
• W2068193025 countsByYear W20681930252022 @default.
• W2068193025 countsByYear W20681930252023 @default.
• W2068193025 crossrefType "journal-article" @default.
• W2068193025 hasAuthorship W2068193025A5005230969 @default.
• W2068193025 hasAuthorship W2068193025A5011179194 @default.
• W2068193025 hasAuthorship W2068193025A5014670369 @default.
• W2068193025 hasAuthorship W2068193025A5021881572 @default.
• W2068193025 hasAuthorship W2068193025A5022120877 @default.
• W2068193025 hasAuthorship W2068193025A5053967338 @default.
• W2068193025 hasAuthorship W2068193025A5069932874 @default.
• W2068193025 hasAuthorship W2068193025A5088481321 @default.
• W2068193025 hasBestOaLocation W20681930252 @default.
• W2068193025 hasConcept C104317684 @default.
• W2068193025 hasConcept C105696609 @default.
• W2068193025 hasConcept C120089663 @default.
• W2068193025 hasConcept C134018914 @default.
• W2068193025 hasConcept C1491633281 @default.
• W2068193025 hasConcept C179185449 @default.
• W2068193025 hasConcept C184235292 @default.
• W2068193025 hasConcept C190283241 @default.
• W2068193025 hasConcept C203522944 @default.
• W2068193025 hasConcept C2778366672 @default.
• W2068193025 hasConcept C2780606744 @default.
• W2068193025 hasConcept C29537977 @default.
• W2068193025 hasConcept C31573885 @default.
• W2068193025 hasConcept C54355233 @default.
• W2068193025 hasConcept C86803240 @default.
• W2068193025 hasConcept C95444343 @default.
• W2068193025 hasConceptScore W2068193025C104317684 @default.
• W2068193025 hasConceptScore W2068193025C105696609 @default.
• W2068193025 hasConceptScore W2068193025C120089663 @default.
• W2068193025 hasConceptScore W2068193025C134018914 @default.
• W2068193025 hasConceptScore W2068193025C1491633281 @default.
• W2068193025 hasConceptScore W2068193025C179185449 @default.
• W2068193025 hasConceptScore W2068193025C184235292 @default.
• W2068193025 hasConceptScore W2068193025C190283241 @default.
• W2068193025 hasConceptScore W2068193025C203522944 @default.
• W2068193025 hasConceptScore W2068193025C2778366672 @default.

• next