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• W2068193118 abstract "An early feature in the development of adipocytes from fibroblast-like precursor cells is the biogenesis of an extracellular basement membrane (Napolitano, 1963; Kuri-Harcuch et al., 1984). Interactions between components of the basement membrane (e.g., collagens) and the surfaces of differentiating adipocytes are thought to regulate subsequent phases of the developmental program. Since fibroblasts principally secrete type I and III collagens whereas type IV collagen is abundant in basement membrane, it appears that a switch in collagen gene expression is a key element in adipocyte differentiation. Little is known about the mechanisms underlying differentiation-dependent changes in collagen expression or the effects of the potent lipolytic cytokine TNF-alpha on collagen mRNA accumulation in preadipocytes and adipocytes. In this study, 3T3-L1 preadipocytes were found to express mRNAs encoding type I, III, and IV procollagens. When 3T3-L1 cells were stimulated to differentiate into adipocytes, the relative concentrations of type I and type III procollagen mRNAs declined by 80-90%. Parallel decreases in the rates of transcription of the procollagen I and procollagen III genes appear to account for the diminished levels of these mRNAs. In contrast, the relative rate of transcription of the procollagen IV gene increased 2.6-fold during adipocyte development. As a consequence, the abundance of type IV procollagen transcripts was elevated in adipocytes. Tumor necrosis factor alpha (TNF-alpha) is a cytokine that stimulates lipolysis, an apparent dedifferentiation of adipocytes, and inhibits transcription of certain adipocyte-specific genes. The effects of TNF-alpha on collagen mRNA levels were dependent upon the state of differentiation of 3T3-L1 cells.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
• W2068193118 created "2016-06-24" @default.
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• W2068193118 date "1989-05-02" @default.
• W2068193118 modified "2023-09-27" @default.
• W2068193118 title "Regulation of collagen gene expression in 3T3-L1 cells. Effects of adipocyte differentiation and tumor necrosis factor .alpha." @default.
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• W2068193118 doi "https://doi.org/10.1021/bi00435a070" @default.
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