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- W2068199454 abstract "The complexation between naproxen and some chemically modified β-cyclodextrins (hydroxyethyl β-cyclodextrin with average substitution degree per anhydroglucose unit 0.6, 1.0 and 1.6; hydroxyproyl β-cyclodextrin with average substitution degree per anhydroglucose unit 0.6 and 0.9) was studied using phase-solubility analysis and molecular modelling. The amorphous carriers exhibit similar solubilizing effects and complexing abilities, which are reflected by a comparable increase in drug dissolution rate to about the same extent from equimolar blends with each chemically modified β-cyclodextrin. X-ray diffractometry and differential scanning calorimetry data indicate a role of the degree of substitution of the carrier in the decrease in crystallinity of naproxen in equimolar blends with chemically modified β-cyclodextrins." @default.
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- W2068199454 date "1995-12-01" @default.
- W2068199454 modified "2023-09-23" @default.
- W2068199454 title "Interaction between naproxen and chemically modified β-cyclodextrins in the liquid and solid state" @default.
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- W2068199454 doi "https://doi.org/10.1016/0928-0987(95)00025-x" @default.
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