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• W2068200417 endingPage "3404" @default.
• W2068200417 startingPage "3391" @default.
• W2068200417 abstract "ABSTRACT Progressive human immunodeficiency virus type 1 (HIV-1) infection is often associated with high plasma virus load (pVL) and impaired CD8 + T-cell function; in contrast, CD8 + T cells remain polyfunctional in long-term nonprogressors. However, it is still unclear whether CD8 + T-cell dysfunction is the cause or the consequence of high pVLs. Here, we conducted a longitudinal functional and phenotypic analysis of virus-specific CD8 + T cells in a cohort of patients with chronic HIV-1 infection. During the initiation and maintenance of successful antiretroviral therapy (ART), we assessed whether the level of pVL was associated with the degree of CD8 + T-cell dysfunction. Under viremic conditions, HIV-specific CD8 + T cells were dysfunctional with respect to cytokine secretion (gamma interferon, interleukin-2 [IL-2], and tumor necrosis factor alpha), and their phenotype suggested limited potential for proliferation. During ART, cytokine secretion by HIV-specific CD8 + T cells was gradually restored, IL-7Rα and CD28 expression increased dramatically, and PD-1 levels declined. Thus, prolonged ART-induced reduction of viral replication and, hence, presumably antigen exposure in vivo, allows a significant functional restoration of CD8 + T cells with the appearance of polyfunctional cells. These findings indicate that the level of pVL as a surrogate for antigen load has a dominant influence on the phenotypic and functional profile of virus-specific CD8 + T cells." @default.
• W2068200417 created "2016-06-24" @default.
• W2068200417 creator A5008537578 @default.
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• W2068200417 creator A5065346505 @default.
• W2068200417 creator A5076131467 @default.
• W2068200417 creator A5086382488 @default.
• W2068200417 date "2008-04-01" @default.
• W2068200417 modified "2023-10-16" @default.
• W2068200417 title "Emergence of Polyfunctional CD8⁺T Cells after Prolonged Suppression of Human Immunodeficiency Virus Replication by Antiretroviral Therapy" @default.
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• W2068200417 doi "https://doi.org/10.1128/jvi.02383-07" @default.
• W2068200417 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2268491" @default.
• W2068200417 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18199637" @default.
• W2068200417 hasPublicationYear "2008" @default.
• W2068200417 type Work @default.
• W2068200417 sameAs 2068200417 @default.

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