Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068204174> ?p ?o ?g. }
- W2068204174 endingPage "665" @default.
- W2068204174 startingPage "656" @default.
- W2068204174 abstract "Protein tau, a major microtubule-binding protein in the brain, comprises six isoforms generated through alternative mRNA splicing. A dysfunctional form of mutant and normal tau is associated or implicated in the pathogenesis of several neurodegenerative disorders. The neuropathological hallmark of these tau-opathies are intraneuronal depositions of fibrillary aggregates of which neurofibrillary tangles are most common. Several distinct transgene mouse models confirmed that tau protein can cause neurodegeneration directly. This study was aimed at identifying proteins that might play a role in the cellular disturbances caused by overexpression of the longest isoform of human tau in the brain of transgenic mice. We found 34 proteins which differed in integrated intensity by a factor of at least 1.5. These proteins could be sorted into several categories. Some of the phenotypic characteristics found in the htau transgenic mice could be related to proteins found in this study. Several proteins are linked to processes involving apoptosis and neuronal death and have been discussed in papers describing neurodegenerative disorders." @default.
- W2068204174 created "2016-06-24" @default.
- W2068204174 creator A5017409703 @default.
- W2068204174 creator A5040417544 @default.
- W2068204174 creator A5040886525 @default.
- W2068204174 creator A5072015473 @default.
- W2068204174 creator A5081889455 @default.
- W2068204174 creator A5084933395 @default.
- W2068204174 date "2002-06-01" @default.
- W2068204174 modified "2023-09-26" @default.
- W2068204174 title "Proteomics analysis of the neurodegeneration in the brain of tau transgenic mice" @default.
- W2068204174 cites W150987474 @default.
- W2068204174 cites W1528219518 @default.
- W2068204174 cites W1554602556 @default.
- W2068204174 cites W1600934558 @default.
- W2068204174 cites W1626453682 @default.
- W2068204174 cites W1646952712 @default.
- W2068204174 cites W1967148091 @default.
- W2068204174 cites W1971165215 @default.
- W2068204174 cites W1975040221 @default.
- W2068204174 cites W1975321314 @default.
- W2068204174 cites W1976628554 @default.
- W2068204174 cites W2008188572 @default.
- W2068204174 cites W2009945323 @default.
- W2068204174 cites W2012781495 @default.
- W2068204174 cites W2018571987 @default.
- W2068204174 cites W2030804652 @default.
- W2068204174 cites W2033742521 @default.
- W2068204174 cites W2041530875 @default.
- W2068204174 cites W2046176730 @default.
- W2068204174 cites W2053791137 @default.
- W2068204174 cites W2057933047 @default.
- W2068204174 cites W2077699648 @default.
- W2068204174 cites W2078790388 @default.
- W2068204174 cites W2081460133 @default.
- W2068204174 cites W2093220216 @default.
- W2068204174 cites W2102709805 @default.
- W2068204174 cites W2108549874 @default.
- W2068204174 cites W2132457979 @default.
- W2068204174 cites W2135476883 @default.
- W2068204174 cites W2159232487 @default.
- W2068204174 cites W2159377066 @default.
- W2068204174 cites W2195134092 @default.
- W2068204174 cites W4296926797 @default.
- W2068204174 cites W81352527 @default.
- W2068204174 doi "https://doi.org/10.1002/1615-9861(200206)2:6<656::aid-prot656>3.0.co;2-z" @default.
- W2068204174 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12112845" @default.
- W2068204174 hasPublicationYear "2002" @default.
- W2068204174 type Work @default.
- W2068204174 sameAs 2068204174 @default.
- W2068204174 citedByCount "39" @default.
- W2068204174 countsByYear W20682041742012 @default.
- W2068204174 countsByYear W20682041742013 @default.
- W2068204174 countsByYear W20682041742016 @default.
- W2068204174 countsByYear W20682041742017 @default.
- W2068204174 countsByYear W20682041742022 @default.
- W2068204174 crossrefType "journal-article" @default.
- W2068204174 hasAuthorship W2068204174A5017409703 @default.
- W2068204174 hasAuthorship W2068204174A5040417544 @default.
- W2068204174 hasAuthorship W2068204174A5040886525 @default.
- W2068204174 hasAuthorship W2068204174A5072015473 @default.
- W2068204174 hasAuthorship W2068204174A5081889455 @default.
- W2068204174 hasAuthorship W2068204174A5084933395 @default.
- W2068204174 hasConcept C102230213 @default.
- W2068204174 hasConcept C104317684 @default.
- W2068204174 hasConcept C141035611 @default.
- W2068204174 hasConcept C142724271 @default.
- W2068204174 hasConcept C153911025 @default.
- W2068204174 hasConcept C169760540 @default.
- W2068204174 hasConcept C194583182 @default.
- W2068204174 hasConcept C2776925932 @default.
- W2068204174 hasConcept C2777739294 @default.
- W2068204174 hasConcept C2778670691 @default.
- W2068204174 hasConcept C2779134260 @default.
- W2068204174 hasConcept C46111723 @default.
- W2068204174 hasConcept C502032728 @default.
- W2068204174 hasConcept C53345823 @default.
- W2068204174 hasConcept C54355233 @default.
- W2068204174 hasConcept C54458228 @default.
- W2068204174 hasConcept C67705224 @default.
- W2068204174 hasConcept C71924100 @default.
- W2068204174 hasConcept C86803240 @default.
- W2068204174 hasConcept C95444343 @default.
- W2068204174 hasConceptScore W2068204174C102230213 @default.
- W2068204174 hasConceptScore W2068204174C104317684 @default.
- W2068204174 hasConceptScore W2068204174C141035611 @default.
- W2068204174 hasConceptScore W2068204174C142724271 @default.
- W2068204174 hasConceptScore W2068204174C153911025 @default.
- W2068204174 hasConceptScore W2068204174C169760540 @default.
- W2068204174 hasConceptScore W2068204174C194583182 @default.
- W2068204174 hasConceptScore W2068204174C2776925932 @default.
- W2068204174 hasConceptScore W2068204174C2777739294 @default.
- W2068204174 hasConceptScore W2068204174C2778670691 @default.
- W2068204174 hasConceptScore W2068204174C2779134260 @default.
- W2068204174 hasConceptScore W2068204174C46111723 @default.
- W2068204174 hasConceptScore W2068204174C502032728 @default.
- W2068204174 hasConceptScore W2068204174C53345823 @default.
- W2068204174 hasConceptScore W2068204174C54355233 @default.