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- W2068205087 abstract "Ways are studied to obtain pyrimidine-rich deoxyoligonucleotides (ON) (n=4−8) which are monofunctionally modified with a trans-[Pt(NH3)2Cl]+ entity: (i) direct platination of the ON with trans-Pt(NH3)2Cl2; (ii) platination with the monoaqua species trans-[Pt(NH3)2Cl(H2O)]+; (iii) platination with trans-Pt(NH3)2(1-MeT)Cl or trans-[Pt(NH3)2(1-MeT)(H2O]+ containing the acid-labile protective group 1-MeT (1-MeT=1-methylthymine anion). Reactions with the oligonucleotides are followed by 1H NMR spectroscopy and HPLC and the products are characterized by ESI MS and 1H NMR. It was the aim of this work to find ways of preparing monofunctionally (trans-PtII(NH3)2) modified ON on a large scale for potential application in the antisense technology." @default.
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- W2068205087 date "1998-03-01" @default.
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- W2068205087 title "Monofunctional trans-PtII(NH3)2 modification of pyrimidine-rich deoxyoligonucleotides: direct platination and use of a protective group" @default.
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