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- W2068206902 endingPage "715" @default.
- W2068206902 startingPage "704" @default.
- W2068206902 abstract "The DNA-dependent protein kinase (DNA-PK) is a trimeric factor originally identified as an enzyme that becomes activated upon incubation with DNA. Genetic defects in either the catalytic subunit (DNA-PK(CS)) or the two Ku components of DNA-PK result in immunodeficiency, radiosensitivity, and premature aging. This combined phenotype is generally attributed to the requirement for DNA-PK in the repair of DNA double strand breaks during various biological processes. However, recent studies revealed that DNA-PK(CS), a member of the growing family of phosphatidylinositol 3-kinases, participates in signal transduction cascades related to apoptotic cell death, telomere maintenance and other pathways of genome surveillance. These manifold functions of DNA-PK(CS) have been associated with an increasing number of protein interaction partners and phosphorylation targets. Here we review the DNA binding properties of DNA-PK(CS) and highlight its ability to interact with an astounding diversity of nucleic acid substrates. This survey indicates that the large catalytic subunit of DNA-PK functions as a sensor of not only broken DNA molecules, but of a wider spectrum of aberrant, unusual, or specialized structures that interrupt the standard double helical conformation of DNA." @default.
- W2068206902 created "2016-06-24" @default.
- W2068206902 creator A5039105364 @default.
- W2068206902 creator A5058838763 @default.
- W2068206902 date "2005-05-01" @default.
- W2068206902 modified "2023-09-24" @default.
- W2068206902 title "More than just strand breaks: the recognition of structural DNA discontinuities by DNA‐dependent protein kinase catalytic subunit" @default.
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- W2068206902 doi "https://doi.org/10.1096/fj.04-3041rev" @default.