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- W2068208511 abstract "• Prolymphocytic leukemia is characterized by a low response rate to agents that are effective in the treatment of chronic lymphocytic leukemia. A 75-year-old man with prolymphocytic leukemia was followed up over a period of 69 months. During that time, he was treated with high-dose chlorambucil plus prednisone; cyclophosphamide administered daily; combinations of vincristine sulfate, prednisone, and cyclophosphamide; irradiation to the spleen; and α-interferon without substantial antitumor effect. The patient had a brief response after splenectomy. When he received low-dose vincristine therapy daily with high-dose prednisone therapy given on alternate days, a fatal tumor lysis syndrome occurred. Although rare, this complication should be kept in mind, particularly in patients who had rapid reduction of tumor cells. (<i>Arch Intern Med</i>1987;147:375-376)" @default.
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- W2068208511 date "1987-02-01" @default.
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- W2068208511 title "Acute Tumor Lysis Syndrome in Prolymphocytic Leukemia" @default.
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- W2068208511 doi "https://doi.org/10.1001/archinte.1987.00370020193063" @default.
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